Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells (Q40351372)

11 June 2018

title

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells (English)

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11 June 2018

author name string

Malika Hale

1

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11 June 2018

Taylor Mesojednik

2

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11 June 2018

Guillermo S Romano Ibarra

3

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11 June 2018

Jaya Sahni

4

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11 June 2018

Alison Bernard

5

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11 June 2018

Karen Sommer

6

1 reference

11 June 2018

Andrew M Scharenberg

7

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11 June 2018

David J Rawlings

8

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11 June 2018

Thor A Wagner

9

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11 June 2018

publication date

28 January 2017

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11 June 2018

published in

Molecular Therapy

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11 June 2018

volume

25

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11 June 2018

issue

3

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11 June 2018

page(s)

570-579

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11 June 2018

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance

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17 June 2018

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17 June 2018

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17 June 2018

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Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

17 June 2018

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Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

17 June 2018

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Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

17 June 2018

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17 June 2018

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Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

17 June 2018

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Antibody-modified T cells: CARs take the front seat for hematologic malignancies

17 June 2018

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Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.

17 June 2018

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Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

17 June 2018

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Broadly neutralizing antiviral antibodies

17 June 2018

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

17 June 2018

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The rising challenge of non-AIDS-defining cancers in HIV-infected patients

17 June 2018

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Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

17 June 2018

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17 June 2018

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17 June 2018

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Adverse outcome analyses of observational data: assessing cardiovascular risk in HIV disease

17 June 2018

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Broad neutralization coverage of HIV by multiple highly potent antibodies

17 June 2018

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Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

17 June 2018

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Protective HIV-specific CD8+ T cells evade Treg cell suppression

17 June 2018

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Direct antibody access to the HIV-1 membrane-proximal external region positively correlates with neutralization sensitivity

17 June 2018

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Dynamics of viral evolution and CTL responses in HIV-1 infection

17 June 2018

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Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation

17 June 2018

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Evidence of persistent low-level viremia in long-term HAART-suppressed, HIV-infected individuals

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363191

Cellular levels of HIV unspliced RNA from patients on combination antiretroviral therapy with undetectable plasma viremia predict the therapy outcome

17 June 2018

1 reference

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Life expectancy after HIV diagnosis based on national HIV surveillance data from 25 states, United States

17 June 2018

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Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection

17 June 2018

1 reference

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Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation

17 June 2018

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Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

17 June 2018

1 reference

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T-cell engineering by a chimeric T-cell receptor with antibody-type specificity for the HIV-1 gp120.

17 June 2018

1 reference

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Cellular immunotherapy for follicular lymphoma using genetically modified CD20-specific CD8+ cytotoxic T lymphocytes

17 June 2018

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Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects

17 June 2018

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Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells

17 June 2018

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HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

17 June 2018

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Identification of a major co-receptor for primary isolates of HIV-1

17 June 2018

1 reference

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Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

17 June 2018

1 reference

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Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells.

17 June 2018

1 reference

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Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus

17 June 2018

1 reference

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Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone

17 June 2018

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Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone

17 June 2018

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Human immunodeficiency virus type 1 T-cell tropism is determined by events prior to provirus formation

17 June 2018

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Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

17 June 2018

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Complete replacement of membrane cholesterol with 4,4',14-trimethyl sterols in a human T cell line defective in lanosterol demethylation

17 June 2018

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Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.

17 June 2018

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Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning

3 July 2018

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Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

20 August 2018

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Increased levels of regulatory T cells (Tregs) in human immunodeficiency virus-infected patients after 5 years of highly active anti-retroviral therapy may be due to increased thymic production of naive Tregs

20 August 2018

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Inefficient human immunodeficiency virus replication in mobile lymphocytes

20 August 2018

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Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV outpatient study.

20 August 2018

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A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy

20 August 2018

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Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells.

20 August 2018

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Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients.

20 August 2018

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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

20 August 2018

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The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.

20 August 2018

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Persistence of HIV-1 Transcription in Peripheral-Blood Mononuclear Cells in Patients Receiving Potent Antiretroviral Therapy

20 August 2018

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HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection

2 December 2018

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Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level

7 January 2021

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Granulocyte-monocyte colony-stimulating factor upregulates HIV-1 replication in monocyte-derived macrophages cultured at low density

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Identifiers

DOI

1 reference

11 June 2018

PMC publication ID

5363191

1 reference

11 June 2018

PubMed publication ID

28143740

1 reference

11 June 2018