GSK-3beta directly phosphorylates and activates MARK2/PAR-1. (Q40356675)

19 September 2017

GSK-3beta directly phosphorylates and activates MARK2/PAR-1. (English)

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19 September 2017

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Shinichi Kosuga

1

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19 September 2017

Etsu Tashiro

2

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19 September 2017

Toshifumi Kajioka

3

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19 September 2017

Mayumi Ueki

4

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19 September 2017

Yoshifumi Shimizu

5

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19 September 2017

Masaya Imoto

6

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19 September 2017

language of work or name

English

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publication date

28 October 2005

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Journal of Biological Chemistry

19 September 2017

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19 September 2017

280

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19 September 2017

52

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19 September 2017

42715-42722

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Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders.

19 September 2017

1 reference

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Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

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The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain.

21 January 2018

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Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression.

21 January 2018

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Tau is essential to beta -amyloid-induced neurotoxicity

21 January 2018

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The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs

21 January 2018

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Phosphorylation of tau by glycogen synthase kinase 3beta in intact mammalian cells influences the stability of microtubules

21 January 2018

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MARKing tau for tangles and toxicity.

21 January 2018

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The glamour and gloom of glycogen synthase kinase-3

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Tau protein kinase I/GSK-3 beta/kinase FA in heparin phosphorylates tau on Ser199, Thr231, Ser235, Ser262, Ser369, and Ser400 sites phosphorylated in Alzheimer disease brain.

21 January 2018

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C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

21 January 2018

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Akt/GSK3beta serine/threonine kinases: evidence for a signalling pathway mediated by familial Alzheimer's disease mutations

21 January 2018

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Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

21 January 2018

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Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.

21 January 2018

1 reference

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Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

21 January 2018

1 reference

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Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

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Alzheimer's disease is a synaptic failure

21 January 2018

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Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

21 January 2018

1 reference

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MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

21 January 2018

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PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila.

21 January 2018

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A volume-sensitive Cl- conductance in a mouse neuroblastoma x rat dorsal root ganglion cell line (F11).

21 January 2018

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Overexpression of BETA2/NeuroD induces neurite outgrowth in F11 neuroblastoma cells

21 January 2018

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mu and delta opioid agonists at low concentrations decrease voltage-dependent K+ currents in F11 neuroblastoma x DRG neuron hybrid cells via cholera toxin-sensitive receptors

21 January 2018

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A molecular cell biology of lithium.

21 January 2018

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Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

21 January 2018

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Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507941200

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507941200

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1

21 January 2018

1 reference

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Mammalian SAD kinases are required for neuronal polarization

21 January 2018

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A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

1 reference

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

21 January 2018

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Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers

21 January 2018

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M507941200

Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507941200

MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507941200

Drosophila par-1 is required for oocyte differentiation and microtubule organization.

21 January 2018

1 reference

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PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

21 January 2018

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Levels of tau phosphorylation at different sites in Alzheimer disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507941200

21 January 2018

Identifiers

DOI

10.1074/JBC.M507941200

1 reference

19 September 2017

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