PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila. (Q47987669)

7 February 2018

title

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila. (English)

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7 February 2018

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Isao Nishimura

1

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7 February 2018

Yufeng Yang

series ordinal

2

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7 February 2018

Bingwei Lu

series ordinal

3

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7 February 2018

language of work or name

English

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publication date

1 March 2004

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7 February 2018

published in

Cell

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7 February 2018

volume

116

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7 February 2018

page(s)

671-682

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7 February 2018

issue

5

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7 February 2018

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

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Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity

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Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity

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Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

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MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

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Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

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7 January 2021

Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.

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7 January 2021

Glycogen synthase kinase 3 phosphorylates recombinant human tau protein at serine-262 in the presence of heparin (or tubulin)

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7 January 2021

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7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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7 January 2021

Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences

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Tau is a candidate gene for chromosome 17 frontotemporal dementia

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Par-1 regulates stability of the posterior determinant Oskar by phosphorylation.

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7 January 2021

The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole.

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7 January 2021

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7 January 2021

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7 January 2021

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

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7 January 2021

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1

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7 January 2021

A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation.

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7 January 2021

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

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7 January 2021

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

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7 January 2021

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

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7 January 2021

10.1016/S0092-8674(04)00170-9

Identifiers

DOI

1 reference

7 February 2018

PubMed ID

15006350

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7 February 2018