Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant (Q40386857)

20 September 2017

title

Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant (English)

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20 September 2017

Jun Ishiko

1

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20 September 2017

Masao Mizuki

2

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20 September 2017

Itaru Matsumura

3

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20 September 2017

Hirohiko Shibayama

4

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20 September 2017

Hiroyuki Sugahara

5

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20 September 2017

Glen Scholz

6

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20 September 2017

Hubert Serve

7

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20 September 2017

Yuzuru Kanakura

8

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20 September 2017

language of work or name

English

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publication date

1 December 2005

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20 September 2017

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20 September 2017

volume

24

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20 September 2017

issue

55

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20 September 2017

page(s)

8144-8153

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Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

20 September 2017

cites work

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Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase

21 January 2018

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Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells

21 January 2018

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Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

21 January 2018

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The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

21 January 2018

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Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor.

21 January 2018

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Necessity of tyrosine 719 and phosphatidylinositol 3'-kinase-mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine kinase with the Asp814Val mutation

21 January 2018

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PDGFRA activating mutations in gastrointestinal stromal tumors.

21 January 2018

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Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.

21 January 2018

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

21 January 2018

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Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor

21 January 2018

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The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations

21 January 2018

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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

21 January 2018

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Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

21 January 2018

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Plat-E: an efficient and stable system for transient packaging of retroviruses

21 January 2018

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Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent

21 January 2018

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Class III receptor tyrosine kinases: role in leukaemogenesis

21 January 2018

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Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

21 January 2018

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p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck.

21 January 2018

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The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3.

21 January 2018

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Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

21 January 2018

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Constitutive activation of c-kit by the juxtamembrane but not the catalytic domain mutations is inhibited selectively by tyrosine kinase inhibitors STI571 and AG1296.

21 January 2018

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

21 January 2018

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Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

21 January 2018

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FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group

21 January 2018

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7 January 2021

Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208957

7 January 2021

Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants

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7 January 2021

Clinical correlates of the presence of the Asp816Val c-kit mutation in the peripheral blood mononuclear cells of patients with mastocytosis

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208957

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Dimensions Publication ID

20 September 2017

1047712504

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1 reference