Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 (Q28181376)

2

0 references

Takahiro Nobukuni

3

0 references

Manel Joaquin

4

0 references

Marta Roccio

5

0 references

Hugo Stocker

6

0 references

Sara C Kozma

7

0 references

Ernst Hafen

8

0 references

Johannes L Bos

9

0 references

George Thomas

Identification of TOR signaling complexes: more TORC for the cell growth engine

10

0 references

language of work or name

English

0 references

publication date

June 2003

0 references

published in

Molecular Cell

0 references

volume

11

0 references

issue

6

0 references

page(s)

1457-66

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

The GTPase superfamily: a conserved switch for diverse cell functions

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Rap-specific GTPase activating protein follows an alternative mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Structural and functional analysis of pp70S6k

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Progress towards understanding the neurobiology of Batten disease or neuronal ceroid lipofuscinosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Mammalian TOR: a homeostatic ATP sensor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Regulation of translation initiation by FRAP/mTOR

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Growth signaling: TSC takes its place.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Activation of p70/p85 S6 kinase by a pathway independent of p21ras

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Action of BTN1, the yeast orthologue of the gene mutated in Batten disease

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

The Ras branch of small GTPases: Ras family members don't fall far from the tree

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Tuberous sclerosis complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Measurement of GTP-bound Ras-like GTPases by activation-specific probes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Multiple independent inputs are required for activation of the p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Stimulation of gene induction and cell growth by the Ras effector Rlf

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

The genetic basis of tuberous sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900220-X

7 January 2021