Signal transduction by Ras-like GTPases: a potential target for anticancer drugs (Q40406776)

20 September 2017

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title

Signal transduction by Ras-like GTPases: a potential target for anticancer drugs (English)

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20 September 2017

1

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20 September 2017

J R Bischoff

2

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PubMed ID

7549466

20 September 2017

F McCormick

series ordinal

3

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20 September 2017

1 January 1995

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20 September 2017

12

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inferred from page(s)

published in

Gene Expression

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20 September 2017

4

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20 September 2017

6

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20 September 2017

345-356

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Association of a Ras-related protein with cytochrome b of human neutrophils

20 September 2017

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12 December 2020

R-ras interacts with rasGAP, neurofibromin and c-raf but does not regulate cell growth or differentiation

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12 December 2020

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein

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12 December 2020

Inhibition by cAMP of Ras-dependent activation of Raf.

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12 December 2020

Association of pRas and pRaf-1 in a complex correlates with activation of a signal transduction pathway

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12 December 2020

Enhancement of the actions of smg p21 GDP/GTP exchange protein by the protein kinase A-catalyzed phosphorylation of smg p21.

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12 December 2020

Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation.

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12 December 2020

Antibody-induced dimerization activates the epidermal growth factor receptor tyrosine kinase

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12 December 2020

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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12 December 2020

Chimeric proteins define variable and essential regions of Ha-ras-encoded protein

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12 December 2020

Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity

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12 December 2020

ras GTPase activating protein: signal transmitter and signal terminator

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12 December 2020

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

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12 December 2020

Function of Ras as a molecular switch in signal transduction

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12 December 2020

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

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12 December 2020

Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor

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12 December 2020

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

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12 December 2020

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12 December 2020

Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation

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12 December 2020

Genetics of signal transduction in invertebrates

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12 December 2020

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

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12 December 2020

Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins.

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12 December 2020

The many roads that lead to Ras.

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12 December 2020

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

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12 December 2020

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

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12 December 2020

Activation of the MAP kinase pathway by the protein kinase raf

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12 December 2020

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

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12 December 2020

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12 December 2020

Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase

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12 December 2020

A signal chain of events

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12 December 2020

Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP-mediated signaling

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12 December 2020

Anti-Ras drugs come of age.

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12 December 2020

Signal transduction by receptors with tyrosine kinase activity

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12 December 2020

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells

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12 December 2020

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

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12 December 2020

Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

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12 December 2020

Activation of Raf as a result of recruitment to the plasma membrane

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12 December 2020

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

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12 December 2020

Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.

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12 December 2020

Programmed cell death and the control of cell survival: lessons from the nervous system

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12 December 2020

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

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12 December 2020

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator

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12 December 2020

Bcl-2 associates with the ras-related protein R-ras p23

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12 December 2020

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins

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12 December 2020

Function and regulation of ras.

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12 December 2020

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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12 December 2020

Binding of GAP to activated PDGF receptors

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12 December 2020

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

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12 December 2020

The GTPase superfamily: a conserved switch for diverse cell functions

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12 December 2020

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

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12 December 2020

Stimulation of p21 ras upon T-cell activation

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12 December 2020

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region

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12 December 2020

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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12 December 2020

Signal transduction. How receptors turn Ras on.

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12 December 2020

The 3Rs of life: Ras, Raf and growth regulation

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12 December 2020

Bcl-2 and the regulation of programmed cell death

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12 December 2020

Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

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12 December 2020

PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

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12 December 2020

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

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12 December 2020

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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12 December 2020

Guanine-nucleotide exchange factors: a family of positive regulators of Ras and related GTPases

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12 December 2020

Toward an understanding of the molecular mechanisms of physiological cell death.

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12 December 2020

GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.

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12 December 2020

The GTPase superfamily: conserved structure and molecular mechanism

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12 December 2020

Sequential protein kinase reactions controlling cell growth and differentiation

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12 December 2020

The ral gene: a new ras related gene isolated by the use of a synthetic probe

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12 December 2020

ras oncogenes in human cancer: a review

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12 December 2020

How receptor tyrosine kinases activate Ras.

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12 December 2020

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

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12 December 2020

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

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12 December 2020

The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion

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12 December 2020

smg/rap1/Krev-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells

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12 December 2020

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

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12 December 2020

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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12 December 2020

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro

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12 December 2020

Complex formation between RAS and RAF and other protein kinases

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12 December 2020

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

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12 December 2020

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

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12 December 2020

Raf-1 activates MAP kinase-kinase

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12 December 2020

Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1

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12 December 2020

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

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12 December 2020

Apoptosis and its role in human disease

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12 December 2020

Proteins regulating Ras and its relatives

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12 December 2020

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation

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12 December 2020

Isolation of cDNA clones and tissue expression of rat ral A and ral B GTP-binding proteins

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12 December 2020

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

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12 December 2020

Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

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12 December 2020

Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target

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12 December 2020

Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes.

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12 December 2020

Platelet-derived growth factor-induced p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or phosphatidylinositol-3-kinase.

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12 December 2020

GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion

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12 December 2020

Expression of the ras-related ralA, rho12 and rab genes in adult mouse tissues

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12 December 2020

Mammalian Ras interacts directly with the serine/threonine kinase Raf

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12 December 2020

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity

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12 December 2020

Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein

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12 December 2020

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts

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12 December 2020

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

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12 December 2020

The IRS-1 signaling system

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12 December 2020

Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction

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12 December 2020

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

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12 December 2020

Diversity in function and regulation of MAP kinase pathways

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12 December 2020

The effector interactions of p21ras

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12 December 2020

Oncogenes and cell death

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12 December 2020

Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells

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12 December 2020

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

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12 December 2020

Requirement for c-ras proteins during viral oncogene transformation

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12 December 2020

Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase

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12 December 2020

Heterologous expression and characterization of the human R-ras gene product

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12 December 2020

Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex

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12 December 2020

GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents

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12 December 2020

v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells

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12 December 2020

Raf meets Ras: completing the framework of a signal transduction pathway

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12 December 2020

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

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12 December 2020

Association between GTPase activators for Rho and Ras families.

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12 December 2020

Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

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12 December 2020

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor

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12 December 2020

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

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12 December 2020

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus

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12 December 2020

Identifiers

PubMed ID

7549466

1 reference

PubMed ID

7549466