CDK2 translational down-regulation during endothelial senescence (Q40415938)

20 September 2017

CDK2 translational down-regulation during endothelial senescence (English)

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20 September 2017

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2

Judah Folkman

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20 September 2017

Deborah A Freedman

1

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PubMed ID

15922732

20 September 2017

language of work or name

English

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publication date

21 April 2005

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Experimental Cell Research

20 September 2017

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20 September 2017

307

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20 September 2017

1

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20 September 2017

118-130

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20 September 2017

Human Cells and Aging

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Mammalian telomeres end in a large duplex loop

7 January 2021

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A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

7 January 2021

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Telomeres shorten during ageing of human fibroblasts

7 January 2021

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Telomere length predicts replicative capacity of human fibroblasts

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

7 January 2021

1 reference

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From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

7 January 2021

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Reverse transcriptase motifs in the catalytic subunit of telomerase

7 January 2021

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Fibroblast growth factor-2, but not vascular endothelial growth factor, upregulates telomerase activity in human endothelial cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Telomerase maintains telomere structure in normal human cells.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Telomerase activity concentrates in the mitotically active segments of human hair follicles

7 January 2021

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Transient increase in telomerase activity of proliferating fibroblasts and endothelial cells in granulation tissue of the human skin

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues

7 January 2021

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Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

7 January 2021

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Extension of life-span by introduction of telomerase into normal human cells

7 January 2021

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Human endothelial cell life extension by telomerase expression

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Association of p16(INK4a) and pRb inactivation with immortalization of human cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Creation of human tumour cells with defined genetic elements

7 January 2021

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

7 January 2021

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Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Telomerase and telomeres: from basic biology to cancer treatment

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Tumor angiogenesis: therapeutic implications

7 January 2021

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Avascular and vascular phases of tumour growth in the chick embryo

7 January 2021

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Telomere length and replicative aging in human vascular tissues

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Senescence and its bypass in the vascular endothelium

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Microarray analysis of replicative senescence

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Post-transcriptional regulation of interleukin 1 alpha in various strains of young and senescent human umbilical vein endothelial cells

7 January 2021

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Subtractive hybridization of mRNA from early passage and senescent endothelial cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization

7 January 2021

1 reference

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

7 January 2021

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Retroviral expression in embryonic stem cells and hematopoietic stem cells

7 January 2021

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Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

7 January 2021

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Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

7 January 2021

1 reference

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Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

7 January 2021

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PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis

7 January 2021

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

7 January 2021

1 reference

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A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status

7 January 2021

1 reference

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Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21WAF1 expression

7 January 2021

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Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

7 January 2021

1 reference

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Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells

7 January 2021

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Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Inactivation of p16 in human mammary epithelial cells by CpG island methylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter

7 January 2021

1 reference

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Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Apoptosis in proliferating, senescent, and immortalized keratinocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence: roles of p16, p21, and cyclin D1

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Long-term cultured IL-2-dependent T cell lines demonstrate p16(INK4a) overexpression, normal pRb/p53, and upregulation of cyclins E or D2.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Cyclin/Cdk-Dependent Initiation of DNA Replication in a Human Cell-Free System

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

Negative feedback regulation of wild-type p53 biosynthesis.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

p53 binds selectively to the 5' untranslated region of cdk4, an RNA element necessary and sufficient for transforming growth factor beta- and p53-mediated translational inhibition of cdk4.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

The helix-loop-helix protein id-1 delays onset of replicative senescence in human endothelial cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.03.025

10.1016/J.YEXCR.2005.03.025

7 January 2021

Identifiers

DOI

1 reference

20 September 2017

1 reference

PubMed ID

15922732