Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding. (Q40444255)

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9 January 2020

title

Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding (English)

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9 January 2020

2

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6

Sarah C R Lummis

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9 January 2020

author name string

Andrew J Thompson

1

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9 January 2020

David C Reeves

3

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S Ling Chan

4

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9 January 2020

P-L Chau

5

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language of work or name

English

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publication date

21 March 2005

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Journal of Biological Chemistry

9 January 2020

published in

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volume

280

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issue

21

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page(s)

20476-20482

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The 5-HT3B subunit is a major determinant of serotonin-receptor function

9 January 2020

cites work

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Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E.

21 January 2018

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Evolutionary history of the ligand-gated ion-channel superfamily of receptors

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The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel (review)

21 January 2018

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

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Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits.

21 January 2018

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Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

21 January 2018

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Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites

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Anxiety over GABA(A) receptor structure relieved by AChBP.

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Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models

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Prediction of 5-HT3 receptor agonist-binding residues using homology modeling.

21 January 2018

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Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine

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Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

21 January 2018

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Rapid and efficient site-specific mutagenesis without phenotypic selection

21 January 2018

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An electrophysiological investigation of the properties of a murine recombinant 5-HT3 receptor stably expressed in HEK 293 cells

21 January 2018

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3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors

21 January 2018

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Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

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Automated docking of substrates to proteins by simulated annealing

21 January 2018

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SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

21 January 2018

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The role of tryptophan residues in the 5-Hydroxytryptamine(3) receptor ligand binding domain

21 January 2018

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Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine

21 January 2018

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Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge?

21 January 2018

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The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor.

21 January 2018

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From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor

21 January 2018

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Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA.

21 January 2018

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Distinct agonist- and antagonist-binding sites on the glycine receptor

21 January 2018

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GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital

21 January 2018

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Analysis of the Ligand Binding Site of the 5-HT 3 Receptor Using Site Directed Mutagenesis: Importance of Glutamate 106

21 January 2018

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Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment

21 January 2018

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Identification of critical residues in loop E in the 5-HT3ASR binding site

21 January 2018

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Interaction of D-tubocurarine analogs with the 5HT3 receptor

21 January 2018

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The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M413610200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15781467%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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