Chymotrypsin-like proteases contribute to human monocytic THP-1 cell as well as human microglial neurotoxicity (Q40444848)

20 September 2017

title

Chymotrypsin-like proteases contribute to human monocytic THP-1 cell as well as human microglial neurotoxicity (English)

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20 September 2017

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Andis Klegeris

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20 September 2017

Patrick L McGeer

series ordinal

2

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20 September 2017

publication date

1 July 2005

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20 September 2017

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20 September 2017

volume

51

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20 September 2017

issue

1

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20 September 2017

page(s)

56-64

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Human microglia convert l-tryptophan into the neurotoxin quinolinic acid

20 September 2017

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Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease

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7 January 2021

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

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Mechanisms underlying neuronal death induced by chromogranin A-activated microglia

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Microglial contribution to oxidative stress in Alzheimer's disease.

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Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.

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beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

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Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: immunophenotypical and functional characterization.

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7 January 2021

Isolation and characterization of adult microglial cells and oligodendrocytes derived from postmortem human brain tissue.

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7 January 2021

A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity

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7 January 2021

Human monocytes/macrophages: NO or no NO?

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7 January 2021

Suppression of A beta-induced monocyte neurotoxicity by antiinflammatory compounds.

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7 January 2021

Neuroinflammatory perspectives on the two faces of Alzheimer's disease

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7 January 2021

Does Parkinson's disease have an immunological basis? The evidence and its therapeutic implications

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7 January 2021

Neurotoxicity of soluble macrophage products in vitro--influence of dexamethasone.

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7 January 2021

Microglial tissue plasminogen activator (tPA) triggers neuronal apoptosis in vitro

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7 January 2021

Identification of Cathepsin B as a Mediator of Neuronal Death Induced by Aβ-activated Microglial Cells Using a Functional Genomics Approach

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7 January 2021

Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1.

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7 January 2021

beta-Amyloid induction of gelatinase B secretion in cultured microglia: inhibition by dexamethasone and indomethacin

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7 January 2021

Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase gene

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7 January 2021

Microglia as a source and target of cytokines

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7 January 2021

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

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7 January 2021

Activated microglia (BV-2) facilitation of TNF-alpha-mediated motor neuron death in vitro.

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7 January 2021

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

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7 January 2021

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

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7 January 2021

Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate.

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7 January 2021

A population-based study of IL4 polymorphisms in multiple sclerosis

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7 January 2021

Microglial secreted cathepsin B induces neuronal apoptosis.

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7 January 2021

Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs).

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7 January 2021

Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor

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7 January 2021

Modulation of human microglia and THP-1 cell toxicity by cytokines endogenous to the nervous system

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Cytokines, chemokines, and cytokine receptors in human microglia

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Cerebrospinal fluid of patients with senile dementia of Alzheimer's type shows an increased inhibition of alpha-chymotrypsin

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Neurocytopathic effects of beta-amyloid-stimulated monocytes: a potential mechanism for central nervous system damage in Alzheimer disease

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Matrix metalloproteinases: they're not just for matrix anymore!

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Inflammation of the brain in Alzheimer's disease: implications for therapy.

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Polymorphisms in inflammatory genes and the risk of Alzheimer disease

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Inflammatory processes in amyotrophic lateral sclerosis

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Association of interleukin-1 beta polymorphisms with idiopathic Parkinson's disease.

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Role of protein kinase C in microglia-induced neurotoxicity in mesencephalic cultures.

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Potentiation of NMDA receptor-mediated synaptic responses by microglia

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Microglia: neuroprotective and neurotrophic cells in the central nervous system

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Microglial functions and proteases

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Review: cytokines and the pathogenesis of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Inflammation and Alzheimer's disease

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain

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https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Human and mouse proteases: a comparative genomic approach

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Cell Type-Specific Roles for Tissue Plasminogen Activator Released by Neurons or Microglia after Excitotoxic Injury

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Microglial-neuronal interactions

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Detection of superoxide production by activated microglia using a sensitive and specific chemiluminescence assay and microglia-mediated PC12h cell death

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

A novel compound, RS-1178, specifically inhibits neuronal cell death mediated by beta-amyloid-induced macrophage activation in vitro

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Distribution of beta amyloid associated proteins in plaques in Alzheimer's disease and in the non-demented elderly

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.20186

7 January 2021

Identifiers

DOI

10.1002/GLIA.20186

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20 September 2017

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