Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity. (Q40460444)

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scientific article published on 17 December 2004

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English	Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity.	scientific article published on 17 December 2004

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity. (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

author name string

K Nielsen

1

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

M Kruhøffer

2

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

T Orntoft

3

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

T Sparre

4

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

H Wang

5

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

C Wollheim

6

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

M C Jørgensen

7

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

J Nerup

8

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

A E Karlsen

9

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

publication date

17 December 2004

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

47

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

2185-2199

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Effects of free fatty acids on beta-cell functions: a possible involvement of peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox

1 reference

https://api.crossref.org/works/10.1007%2FS00125-004-1578-1

21 January 2018

Arginine metabolism: nitric oxide and beyond

1 reference

https://api.crossref.org/works/10.1007%2FS00125-004-1578-1

21 January 2018

Macrophages can convert citrulline into arginine

1 reference

https://api.crossref.org/works/10.1007%2FS00125-004-1578-1

21 January 2018

Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signals derived from glucose metabolism are required for glucose regulation of pancreatic islet GLUT2 mRNA and protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Target cell expression of suppressor of cytokine signaling-1 prevents diabetes in the NOD mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Massive parallel gene expression profiling of RINm5F pancreatic islet beta-cells stimulated with interleukin-1beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteome Analysis of Interleukin-1 -Induced Changes in Protein Expression in Rat Islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the pathogenesis of IDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mRNA Profiling of Rat Islet Tumors Reveals Nkx 6.1 as a β-Cell-specific Homeodomain Transcription Factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione in defense and signaling: lessons from a small thiol

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and functional characterization of the rat glutamine synthetase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 1beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of interleukin-1 in the pathogenesis of IDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1 beta indicate a perturbation in the mitochondrial function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additional mutations in argininosuccinate synthetase causing citrullinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell maturation leads to in vitro sensitivity to cytotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of the selective toxicity of alloxan to the pancreatic B cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloned cell lines from a transplantable islet cell tumor are heterogeneous and express cholecystokinin in addition to islet hormones

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-1β induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione protects a human insulinoma cell line from tumor necrosis factor-alpha-mediated cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic and transcriptomic analysis of interleukin-1beta treated lung carcinoma cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and sequencing of rat kidney L-arginine:glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional networks controlling pancreatic development and beta cell function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression monitoring by hybridization to high-density oligonucleotide arrays

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD200 and membrane protein interactions in the control of myeloid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the type III InsP3 receptor and its role in beta cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic Production of Interferon-Gamma Inducing Factor (IGIF) Versus Local IFN-γ Expression Involved in the Development of Th1 Insulitis in NOD Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific expression of transfected human insulin genes in pluripotent clonal rat insulinoma lines induced during passage in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential role of the JNK and p38 MAPK pathway in c-Myc- and s-Myc-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein expression changes in a cell system of beta-cell maturation reflect an acquired sensitivity to IL-1beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15605246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-004-1578-1

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

ResearchGate publication ID

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