Transcriptional networks controlling pancreatic development and beta cell function. (Q35857682)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15298336%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

review article

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title

Transcriptional networks controlling pancreatic development and beta cell function (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15298336%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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Joan Marc Servitja Duque

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15298336%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Jorge Ferrer

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15298336%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

author name string

Servitja JM

1

1 reference

10 August 2017

Ferrer J

2

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10 August 2017

1 April 2004

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15298336%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15298336%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

volume

47

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15298336%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

page(s)

597-613

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31 December 2019

issue

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15298336%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s00125-004-1368-9

31 December 2019

exact match

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The islet beta cell-enriched RIPE3b1/Maf transcription factor regulates pdx-1 expression

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The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

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Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

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Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

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Increased islet apoptosis in Pdx1+/- mice

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Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

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A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young

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Dissecting the transcriptional network of pancreatic islets during development and differentiation

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Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas

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Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.

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12 December 2020

Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function

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12 December 2020

Perspective: Postnatal pancreatic beta cell growth

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12 December 2020

Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction

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12 December 2020

Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter

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12 December 2020

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

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12 December 2020

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

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12 December 2020

Network motifs in the transcriptional regulation network of Escherichia coli

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12 December 2020

Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1

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12 December 2020

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion

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12 December 2020

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

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12 December 2020

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

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12 December 2020

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

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12 December 2020

Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas

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12 December 2020

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

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12 December 2020

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

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12 December 2020

Chromatin immunoprecipitation using isolated islets of Langerhans.

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12 December 2020

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

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12 December 2020

Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells

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12 December 2020

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

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12 December 2020

Notochord repression of endodermal Sonic hedgehog permits pancreas development

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12 December 2020

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

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12 December 2020

Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development

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12 December 2020

Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and rats

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12 December 2020

Notch signalling controls pancreatic cell differentiation

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12 December 2020

Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development

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12 December 2020

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

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12 December 2020

Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites.

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12 December 2020

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12 December 2020

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12 December 2020

Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3

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12 December 2020

IPF1, a homeodomain-containing transactivator of the insulin gene

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12 December 2020

The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade.

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12 December 2020

Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1

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12 December 2020

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism

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12 December 2020

Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization

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12 December 2020

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

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12 December 2020

Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene

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12 December 2020

Nanog: a new recruit to the embryonic stem cell orchestra

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12 December 2020

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

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12 December 2020

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12 December 2020

Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1

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12 December 2020

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12 December 2020

Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression

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12 December 2020

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

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12 December 2020

Neurogenin3 activates the islet differentiation program while repressing its own expression

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12 December 2020

BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells.

1 reference

12 December 2020

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

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12 December 2020

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

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12 December 2020

Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutations

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12 December 2020

Cell replacement therapy for type 1 diabetes

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12 December 2020

Pdx1 restores beta cell function in Irs2 knockout mice

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12 December 2020

Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein

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12 December 2020

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

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12 December 2020

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

1 reference

12 December 2020

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

1 reference

12 December 2020

Mathematical modeling of gene networks

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12 December 2020

Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9

1 reference

12 December 2020

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells

1 reference

12 December 2020

Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3

1 reference

12 December 2020

Regulation of the pancreatic pro-endocrine gene neurogenin3.

1 reference

12 December 2020

Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

1 reference

12 December 2020

Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY.

1 reference

12 December 2020

An ultrastructural analysis of the developing embryonic pancreas

1 reference

12 December 2020

Experimental conversion of liver to pancreas

1 reference

12 December 2020

Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1

1 reference

12 December 2020

Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development

1 reference

12 December 2020

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors

1 reference

12 December 2020

Oct-4: gatekeeper in the beginnings of mammalian development.

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12 December 2020

A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells

1 reference

12 December 2020

Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells

1 reference

12 December 2020

Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta.

1 reference

12 December 2020

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

12 December 2020

Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene

1 reference

12 December 2020

IRS proteins and the common path to diabetes

1 reference

12 December 2020

Notch signaling controls multiple steps of pancreatic differentiation

1 reference

12 December 2020

Transcriptional regulatory networks in Saccharomyces cerevisiae

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12 December 2020

Opposing actions of Arx and Pax4 in endocrine pancreas development

1 reference

12 December 2020

Notch gene expression during pancreatic organogenesis

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12 December 2020

Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6

1 reference

12 December 2020

Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice

1 reference

12 December 2020

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation

1 reference

12 December 2020

Distinct gene expression programs function in progenitor and mature islet cells.

1 reference

12 December 2020

Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect

1 reference

12 December 2020

Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.

1 reference

12 December 2020

Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms.

1 reference

12 December 2020

The large-scale organization of metabolic networks

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12 December 2020

Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells

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12 December 2020

Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification

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12 December 2020

Error and attack tolerance of complex networks

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12 December 2020

Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4

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12 December 2020

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance

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12 December 2020

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta

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12 December 2020

Two Pax2/5/8-binding sites in Engrailed2 are required for proper initiation of endogenous mid-hindbrain expression

1 reference

12 December 2020

Control of endodermal endocrine development by Hes-1

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12 December 2020

The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas.

1 reference

12 December 2020

Maturity-onset diabetes of the young caused by a balanced translocation where the 20q12 break point results in disruption upstream of the coding region of hepatocyte nuclear factor-4alpha (HNF4A) gene.

1 reference

12 December 2020

Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse

1 reference

12 December 2020

The onecut transcription factor HNF6 is required for normal development of the biliary tract

1 reference

12 December 2020

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

1 reference

12 December 2020

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

1 reference

12 December 2020

A genetic switch in pancreatic beta-cells: implications for differentiation and haploinsufficiency.

1 reference

12 December 2020

Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes

1 reference

12 December 2020

Tissue-specific and developmental regulation of the rat insulin II gene enhancer, RIPE3, in transgenic mice.

1 reference

12 December 2020

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor

1 reference

12 December 2020

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene

1 reference

12 December 2020

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

1 reference

12 December 2020

Multistability: a major means of differentiation and evolution in biological systems

1 reference

12 December 2020

Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.

1 reference

12 December 2020

A pancreatic beta -cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3beta (HNF-3beta ), HNF-1alpha, and SPs transcription factors

1 reference

12 December 2020

The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene

1 reference

12 December 2020

Regulation of insulin gene transcription

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12 December 2020

Insulin-promoter-factor 1 is required for pancreas development in mice

1 reference

12 December 2020

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

1 reference

12 December 2020

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

1 reference

12 December 2020

Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm

1 reference

12 December 2020

Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

1 reference

12 December 2020

Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice.

1 reference

12 December 2020

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

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12 December 2020

Conversion of biliary system to pancreatic tissue in Hes1-deficient mice

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12 December 2020

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

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12 December 2020

Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation

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12 December 2020