Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP. (Q40463082)

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scientific article published on February 2005

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English	Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.	scientific article published on February 2005

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scholarly article

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8 January 2020

Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP (English)

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8 January 2020

pharmacodynamics

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8

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8 January 2020

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Cummings J

1

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8 January 2020

Ward TH

2

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8 January 2020

LaCasse E

3

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8 January 2020

Lefebvre C

4

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8 January 2020

St-Jean M

5

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8 January 2020

Durkin J

6

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8 January 2020

Ranson M

7

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8 January 2020

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1 February 2005

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8 January 2020

British Journal of Cancer

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8 January 2020

92

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8 January 2020

3

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8 January 2020

532-538

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8 January 2020

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

1 reference

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22 September 2017

Disturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomas

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22 September 2017

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

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22 September 2017

Antagonizing XIAP-mediated caspase-3 inhibition. Achilles' heel of cancers?

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22 September 2017

The inhibitors of apoptosis: there is more to life than Bcl2.

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22 September 2017

Elevated expression of inhibitor of apoptosis proteins in prostate cancer

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22 September 2017

Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma

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22 September 2017

XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells

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22 September 2017

Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis

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A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera

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22 September 2017

Simultaneous detection of apoptosis and proliferation in colorectal carcinoma by multiparameter flow cytometry allows separation of high and low‐turnover tumors with distinct clinical outcome

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22 September 2017

How much gets there and what does it do?: The need for better pharmacokinetic and pharmacodynamic endpoints in contemporary drug discovery and development

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22 September 2017

Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer

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22 September 2017

Reprieval from execution: the molecular basis of caspase inhibition

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22 September 2017

XIAP: apoptotic brake and promising therapeutic target.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362094

22 September 2017

Characterization of XIAP-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362094

22 September 2017

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362094

22 September 2017

Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines

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22 September 2017

The biochemistry of apoptosis

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22 September 2017

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias

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22 September 2017

Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis

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22 September 2017

M30 expression demonstrates apoptotic cells, correlates with in situ end-labeling, and is associated with Ki-67 expression in large intestinal neoplasms.

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17 June 2018

XIAP expression is an independent prognostic marker in clear-cell renal carcinomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2362094

20 August 2018

High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia

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Comprehensive validation of a real-time quantitative bcr-abl assay for clinical laboratory use.

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Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity.

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20 August 2018

Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo.

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Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro.

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Analytical validation of a real-time reverse transcription-polymerase chain reaction quantitation of different transcripts of the Wilms' tumor suppressor gene (WT1).

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20 August 2018

Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model

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An immunohistochemical study of the clearance of apoptotic cellular fragments

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Immunohistochemical detection of cytokeratin 18 and its neo-epitope in human salivary glands and pleomorphic adenomas

1 reference

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Expression of a Cytokeratin 18 Neo-epitope is a Specific Marker for Trophoblast Apoptosis in Human Placenta

1 reference

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Bioanalytical method validation--a revisit with a decade of progress

1 reference

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12 December 2020

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XIAP, the guardian angel

1 reference

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12 December 2020

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Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients

1 reference

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Workshop on bioanalytical methods validation for macromolecules: summary report

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Apoptosis induced by low-dose and low-dose-rate radiation

1 reference

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The inhibitors of apoptosis (IAPs) and their emerging role in cancer

1 reference

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12 December 2020

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10.1038/SJ.BJC.6602363

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8 January 2020

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8 January 2020

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8 January 2020

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