Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics (Q40513940)

21 September 2017

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics (English)

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21 September 2017

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Dan C McManus

1

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21 September 2017

Charles A Lefebvre

2

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21 September 2017

Gabriele Cherton-Horvat

3

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21 September 2017

Martine St-Jean

4

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21 September 2017

Ekambar R Kandimalla

5

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21 September 2017

Sudhir Agrawal

6

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21 September 2017

Stephen J Morris

7

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21 September 2017

Jon P Durkin

8

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21 September 2017

Eric C Lacasse

9

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21 September 2017

language of work or name

English

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publication date

1 October 2004

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21 September 2017

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21 September 2017

23

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21 September 2017

49

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21 September 2017

8105-8117

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207967

21 September 2017

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Human ICE/CED-3 protease nomenclature

21 January 2018

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 January 2018

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Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death

21 January 2018

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Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro.

21 January 2018

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Structural basis of caspase-7 inhibition by XIAP

21 January 2018

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The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

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Identification of caspase-independent apoptosis in epithelial and cancer cells

21 January 2018

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X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells

21 January 2018

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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

21 January 2018

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X-linked IAP is a direct inhibitor of cell-death proteases

21 January 2018

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

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Killing the messenger: short RNAs that silence gene expression

21 January 2018

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The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein

21 January 2018

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

21 January 2018

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Real time quantitative PCR

21 January 2018

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Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes

21 January 2018

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Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

21 January 2018

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The inhibitors of apoptosis: there is more to life than Bcl2.

21 January 2018

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Life and death decisions: the role of the IAPs in modulating programmed cell death

21 January 2018

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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

21 January 2018

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Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells

21 January 2018

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Apoptosis-targeted therapies for cancer

21 January 2018

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Structural basis for the inhibition of caspase-3 by XIAP

21 January 2018

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The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

21 January 2018

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Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

21 January 2018

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TRAIL: a potential agent for cancer therapy

21 January 2018

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Mechanisms of caspase activation and inhibition during apoptosis

21 January 2018

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An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7

21 January 2018

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Adenovirus-mediated gene transfer of inhibitors of apoptosis protein delays apoptosis in cerebellar granule neurons.

21 January 2018

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Activation of the interferon system by short-interfering RNAs

21 January 2018

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Reprieval from execution: the molecular basis of caspase inhibition

21 January 2018

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

21 January 2018

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A single BIR domain of XIAP sufficient for inhibiting caspases

21 January 2018

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The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

21 January 2018

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

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Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop

21 January 2018

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Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma.

21 January 2018

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Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation

21 January 2018

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

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Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

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Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis

21 January 2018

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7 January 2021

XIAP, the guardian angel

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7 January 2021

Bcl-X(L) expression and its downregulation by a novel retinoid in breast carcinoma cells

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7 January 2021

Structural Basis of Caspase Inhibition by XIAP

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7 January 2021

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

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7 January 2021

Involvement of the bcl-2 gene in human follicular lymphoma

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207967

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Dimensions Publication ID

21 September 2017

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