Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. (Q40478675)

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English	Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.	scientific article

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6 January 2020

Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex (English)

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6 January 2020

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6 January 2020

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Felicia Miller

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6 January 2020

Roman Osman

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6 January 2020

Zhen-Qiang Pan

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20 December 2004

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6 January 2020

Journal of Biological Chemistry

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6 January 2020

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6 January 2020

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6 January 2020

7985-7996

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6 January 2020

Identification of the von Hippel-Lindau disease tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype

1 reference

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21 January 2018

Advances in the staging of renal cell carcinoma

1 reference

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21 January 2018

Emerging roles of ubiquitin in transcription regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413160200

21 January 2018

Comparison of simple potential functions for simulating liquid water

1 reference

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21 January 2018

All-atom empirical potential for molecular modeling and dynamics studies of proteins

1 reference

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21 January 2018

Computational investigations of structural changes resulting from point mutations in a collagen-like peptide

1 reference

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21 January 2018

Mutations of the VHL gene in sporadic renal cell carcinoma: definition of a risk factor for VHL patients to develop an RCC

1 reference

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21 January 2018

Mechanisms underlying ubiquitination

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21 January 2018

A dynamic model for the allosteric mechanism of GroEL

1 reference

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Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation

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Analysis of a 10-ns molecular dynamics simulation of mouse acetylcholinesterase

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Protein concerted motions in the DNA-human topoisomerase I complex.

1 reference

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Germline mutations in the vhl gene in patients presenting with phaeochromocytomas

1 reference

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21 January 2018

Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma

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Identifiers

10.1074/JBC.M413160200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15611064%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15611064%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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