Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation (Q40484358)

20 September 2017

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation (English)

1 reference

20 September 2017

4

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3 June 2020

Leal Oburoglu

6

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3 June 2020

Julien C Marie

13

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3 June 2020

author name string

Dorota Klysz

1

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3 June 2020

Xuguang Tai

2

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3 June 2020

Philippe A Robert

3

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3 June 2020

Gaspard Cretenet

5

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3 June 2020

Cédric Mongellaz

7

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3 June 2020

Stefan Floess

8

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3 June 2020

Vanessa Fritz

9

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3 June 2020

Maria I Matias

10

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3 June 2020

Carmen Yong

11

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3 June 2020

Natalie Surh

12

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3 June 2020

Jochen Huehn

14

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3 June 2020

Valérie Zimmermann

15

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3 June 2020

Sandrina Kinet

16

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3 June 2020

Valérie Dardalhon

17

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3 June 2020

Naomi Taylor

18

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3 June 2020

language of work or name

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29 September 2015

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20 September 2017

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3 June 2020

volume

8

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3 June 2020

issue

396

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3 June 2020

page(s)

ra97

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Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

3 June 2020

cites work

1 reference

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Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind Glut-1 on activated CD4+ and CD8+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis.

21 January 2018

1 reference

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IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival

21 January 2018

1 reference

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Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation

21 January 2018

1 reference

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Metabolic pathways in T cell fate and function

21 January 2018

1 reference

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Metabolic switching and fuel choice during T-cell differentiation and memory development

21 January 2018

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Metabolic checkpoints in activated T cells

21 January 2018

1 reference

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Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

21 January 2018

1 reference

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HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

21 January 2018

1 reference

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De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.

21 January 2018

1 reference

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

21 January 2018

1 reference

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PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

Regulation of immune responses by mTOR.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

Glutamine transport and human hepatocellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

Oral glutamine attenuates cyclophosphamide-induced oxidative stress in the bladder but does not prevent hemorrhagic cystitis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

Glutamine, gene expression, and cell function

21 January 2018

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

21 January 2018

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Regulation of glutaminase activity and glutamine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.AAB2610

Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells

21 January 2018

1 reference

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SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

21 January 2018

1 reference

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Epigenetic control of the foxp3 locus in regulatory T cells

21 January 2018

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Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis.

21 January 2018

1 reference

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Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells

21 January 2018

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Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

21 January 2018

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Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells

21 January 2018

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Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

21 January 2018

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The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.

21 January 2018

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Glutaminolysis activates Rag-mTORC1 signaling.

21 January 2018

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ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells.

21 January 2018

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Bidirectional transport of amino acids regulates mTOR and autophagy

21 January 2018

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Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

21 January 2018

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Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance

21 January 2018

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

21 January 2018

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The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

21 January 2018

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

21 January 2018

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Glutamine addiction: a new therapeutic target in cancer

21 January 2018

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