Mutant ras-induced proliferation of human thyroid epithelial cells requires three effector pathways (Q40516586)

21 September 2017

Mutant ras-induced proliferation of human thyroid epithelial cells requires three effector pathways (English)

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21 September 2017

Ali Bounacer

1

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21 September 2017

Alex McGregor

2

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21 September 2017

Julia Skinner

3

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21 September 2017

Jane Bond

4

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21 September 2017

Zara Poghosyan

5

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21 September 2017

David Wynford-Thomas

6

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21 September 2017

language of work or name

English

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publication date

1 October 2004

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21 September 2017

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23

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47

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7839-7845

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208085

21 September 2017

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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

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Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation.

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RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

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Concomitant activation of MEK-1 and Rac-1 increases the proliferative potential of thyroid epithelial cells, without affecting their differentiation.

21 January 2018

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

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Potential regulation of ADP-ribosylation factor 6 signalling by phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451

21 January 2018

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Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway

21 January 2018

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Ral-GTPases: approaching their 15 minutes of fame

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Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies

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Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras.

21 January 2018

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An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity

21 January 2018

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TC21 and Ras share indistinguishable transforming and differentiating activities

21 January 2018

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Spatial regulation of the exocyst complex by Rho1 GTPase

21 January 2018

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Distinct requirements for Ras oncogenesis in human versus mouse cells

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MaRX: an approach to genetics in mammalian cells.

21 January 2018

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Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.

21 January 2018

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Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

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Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity

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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

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Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles

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Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection

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Functional association between Arf and RalA in active phospholipase D complex

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21 January 2018

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RalGDS functions in Ras- and cAMP-mediated growth stimulation

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Differential effects of protein kinase A on Ras effector pathways

21 January 2018

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

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Ral GTPases regulate exocyst assembly through dual subunit interactions

21 January 2018

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The small GTPase RalA targets filamin to induce filopodia

21 January 2018

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Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells

21 January 2018

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Phospholipase D as an effector for ADP-ribosylation factor in the regulation of vesicular traffic.

21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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Role for phospholipase D in receptor-mediated endocytosis

21 January 2018

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The exocyst complex binds the small GTPase RalA to mediate filopodia formation

21 January 2018

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Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase

21 January 2018

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Multiple Ras functions can contribute to mammalian cell transformation

21 January 2018

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Loss of dependence on IGF-1 for proliferation of human thyroid adenoma cells

21 January 2018

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Ras caught in another affair: the exchange factors for Ral.

21 January 2018

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Stimulation of gene induction and cell growth by the Ras effector Rlf

21 January 2018

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Activation of the small GTPase Ral in platelets.

21 January 2018

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Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6

21 January 2018

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Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation

21 January 2018

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208085

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1208085

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Dimensions Publication ID

21 September 2017

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1 reference