The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity (Q40525768)

21 September 2017

title

The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity (English)

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21 September 2017

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Calbó J

1

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21 September 2017

Serna C

2

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21 September 2017

Garriga J

3

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21 September 2017

Graña X

4

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21 September 2017

Mazo A

5

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21 September 2017

publication date

1 October 2004

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Cell Death & Differentiation

21 September 2017

published in

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21 September 2017

volume

11

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21 September 2017

issue

10

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21 September 2017

page(s)

1055-1065

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401481

21 September 2017

exact match

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cites work

Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

21 January 2018

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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

21 January 2018

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Growth suppression by p16ink4 requires functional retinoblastoma protein

21 January 2018

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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Distinct roles for cyclin-dependent kinases in cell cycle control

21 January 2018

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Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

21 January 2018

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G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression

21 January 2018

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G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts

21 January 2018

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Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells

21 January 2018

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Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein

21 January 2018

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Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo

21 January 2018

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Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

21 January 2018

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Adenovirus-mediated wt-p16 reintroduction induces cell cycle arrest or apoptosis in pancreatic cancer

21 January 2018

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Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells.

21 January 2018

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Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product

21 January 2018

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Genetic background determines the response to adenovirus-mediated wild-type p53 expression in pancreatic tumor cells.

21 January 2018

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Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation

21 January 2018

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PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro

21 January 2018

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Phosphorylation site specificity of the CDC2-related kinase PITALRE.

21 January 2018

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E1A blocks hyperphosphorylation of p130 and p107 without affecting the phosphorylation status of the retinoblastoma protein

21 January 2018

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Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes

21 January 2018

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

21 January 2018

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

21 January 2018

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Proliferation of cancer cells despite CDK2 inhibition.

21 January 2018

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Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

21 January 2018

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Requirement for cyclin D3 in lymphocyte development and T cell leukemias

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells

21 January 2018

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p21Waf1/Cip1 as a therapeutic target in breast and other cancers

21 January 2018

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pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F Activities

21 January 2018

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Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis

21 January 2018

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Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

Requirements for cell cycle arrest by p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

7 January 2021

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

7 January 2021

Down-regulation of bcl-2 is associated with p16INK4-mediated apoptosis in non-small cell lung cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

7 January 2021

Use of recombinant adenovirus for metabolic engineering of mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

7 January 2021

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

7 January 2021

Cdk2-dependent phosphorylation and functional inactivation of the pRB-related p130 protein in pRB(-), p16INK4A(+) tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

7 January 2021

E1A modulates phosphorylation of p130 and p107 by differentially regulating the activity of G1/S cyclin/CDK complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

7 January 2021

Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

7 January 2021

Cyclin E in human cancers.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401481

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401481

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Dimensions Publication ID

21 September 2017

1006882457

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1 reference