p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance (Q40544871)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15199150%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance (English)

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29 December 2019

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4

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29 December 2019

Maureen Murphy

6

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29 December 2019

author name string

Zaineb R Abdul Razak

1

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29 December 2019

Robert J Varkonyi

2

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29 December 2019

Michelle Kulp-McEliece

3

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29 December 2019

Joseph R Testa

5

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29 December 2019

Dominique Broccoli

7

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29 December 2019

language of work or name

English

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publication date

1 July 2004

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Molecular and Cellular Biology

29 December 2019

published in

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29 December 2019

volume

24

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29 December 2019

issue

13

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29 December 2019

page(s)

5967-5977

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A DNA damage checkpoint response in telomere-initiated senescence

29 December 2019

cites work

1 reference

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DNA damage foci at dysfunctional telomeres

22 September 2017

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Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1

22 September 2017

1 reference

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Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression

22 September 2017

1 reference

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p53 null mutations are associated with a telomerase negative phenotype in ovarian carcinoma

22 September 2017

1 reference

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Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity

22 September 2017

1 reference

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The processing of Holliday junctions by BLM and WRN helicases is regulated by p53

22 September 2017

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Hypoxia links ATR and p53 through replication arrest

22 September 2017

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Alternative lengthening of telomeres in mammalian cells

22 September 2017

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The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

22 September 2017

1 reference

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Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

22 September 2017

1 reference

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DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells

22 September 2017

1 reference

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Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events

22 September 2017

1 reference

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p53 accumulates but is functionally impaired when DNA synthesis is blocked

22 September 2017

1 reference

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Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

22 September 2017

1 reference

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NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

22 September 2017

1 reference

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Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA

22 September 2017

1 reference

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Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae

22 September 2017

1 reference

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Hot-spot mutants of p53 core domain evince characteristic local structural changes.

22 September 2017

1 reference

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The PML nuclear bodies: actors or extras?

22 September 2017

1 reference

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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

22 September 2017

1 reference

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PML induces a novel caspase-independent death process

22 September 2017

1 reference

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Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

A survey of telomerase activity in human cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Inactivation of p53 results in high rates of homologous recombination

22 September 2017

1 reference

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Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

22 September 2017

1 reference

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p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

22 September 2017

1 reference

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In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes

22 September 2017

1 reference

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An alternative pathway for yeast telomere maintenance rescues est1- senescence

22 September 2017

1 reference

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High-frequency recombination mediated by polyomavirus large T antigen defective in replication

22 September 2017

1 reference

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WAF1, a potential mediator of p53 tumor suppression

22 September 2017

1 reference

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

22 September 2017

1 reference

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Telomere elongation in immortal human cells without detectable telomerase activity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

p53 binds telomeric single strand overhangs and t-loop junctions in vitro

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

SV40 infection induces telomerase activity in human mesothelial cells.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Telomere maintenance by telomerase and by recombination can coexist in human cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Telomere maintenance by recombination in human cells.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

ALT-associated PML bodies are present in viable cells and are enriched in cells in the G(2)/M phase of the cell cycle.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

A comparison of the biological activities of wild-type and mutant p53.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Immortalized cells with no detectable telomerase activity. A review

25 September 2017

1 reference

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Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Essential role for p53-mediated transcription in E1A-induced apoptosis

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Loss of wild-type p53 function is responsible for upregulated homologous recombination in immortal rodent fibroblasts.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

A human-derived probe, p82H, hybridizes to the centromeres of gorilla, chimpanzee, and orangutan

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

Expression of two mucin antigens in cultured human ovarian surface epithelium: Influence of a family hostory of ovarian cancer

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=480899

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

20 August 2018

1 reference

12 December 2020

Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body

1 reference

12 December 2020

Dissociation of the recombination control and the sequence-specific transactivation function of P53

1 reference

12 December 2020

Distinct regions of p53 have a differential role in transcriptional activation and repression functions

1 reference

12 December 2020

p53 transactivation domain mutant Q22, S23 is impaired for repression of promoters and mediation of apoptosis

1 reference

12 December 2020

Human p53 binds Holliday junctions strongly and facilitates their cleavage

1 reference

12 December 2020

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1 reference

12 December 2020

10.1128/MCB.24.13.5967-5977.2004

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15199150%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15199150%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

15199150

1 reference