An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency (Q40546345)

21 September 2017

An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency (English)

1 reference

21 September 2017

1 reference

1 reference

Ta-Chiang Liu

1

1 reference

21 September 2017

Gunnel Hallden

2

1 reference

21 September 2017

Yaohe Wang

3

1 reference

21 September 2017

Gabriel Brooks

4

1 reference

21 September 2017

Jennelle Francis

5

1 reference

21 September 2017

Nick Lemoine

6

1 reference

21 September 2017

David Kirn

7

1 reference

21 September 2017

1 June 2004

1 reference

21 September 2017

1 reference

21 September 2017

9

1 reference

21 September 2017

6

1 reference

21 September 2017

786-803

1 reference

Replicating viruses as selective cancer therapeutics

21 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Oncolytic biotherapy: a novel therapeutic plafform

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Replication-selective virotherapy for cancer: Biological principles, risk management and future directions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Replication-selective microbiological agents: fighting cancer with targeted germ warfare

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Replication-selective adenoviruses as oncolytic agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Conditionally replicating herpes vectors for cancer therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

ONYX-015: clinical data are encouraging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

A tale of two trials: selectively replicating herpesviruses for brain tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: intratumoral spread and distribution effects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

7 January 2021

Viruses and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Regulation of the cell cycle and apoptosis by the oncogenes of adenovirus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

BCL-2 family members and the mitochondria in apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Bcl-2 blocks p53-dependent apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

The Bcl2 family: regulators of the cellular life-or-death switch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

The role of the Bcl-2 protein family in cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

p53 mutations in human cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Defects in the apoptotic machinery of cancer cells: role in drug resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Cell surface Death Receptor signaling in normal and cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Immune responses to adenoviruses: viral evasion mechanisms and their implications for the clinic.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Adenovirus immunoregulatory genes and their cellular targets

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Interaction of E1B 19K with Bax is required to block Bax-induced loss of mitochondrial membrane potential and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

E1B 19K inhibits Fas-mediated apoptosis through FADD-dependent sequestration of FLICE.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

TNFalpha and IFNgamma induced by innate anti-adenoviral immune responses inhibit adenovirus-mediated transgene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Evaluation of E1B gene-attenuated replicating adenoviruses for cancer gene therapy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Infection of Mouse Liver by Human Adenovirus Type 5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Adenovirus 2 Ip+ locus codes for a 19 kd tumor antigen that plays an essential role in cell transformation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Bak and Bax function to limit adenovirus replication through apoptosis induction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

The E3-11.6-kDa adenovirus death protein (ADP) is required for efficient cell death: characterization of cells infected with adp mutants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Adenovirus E1B 19-kDa death suppressor protein interacts with Bax but not with Bad

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Requirement of BAX for efficient adenovirus-induced apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Adenovirus E1A oncogene expression in tumor cells enhances killing by TNF-related apoptosis-inducing ligand (TRAIL).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Inhibition of TRAIL-induced apoptosis and forced internalization of TRAIL receptor 1 by adenovirus proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Armed therapeutic viruses: strategies and challenges to arming oncolytic viruses with therapeutic genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

Regulation of apoptosis by viral gene products

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

7 January 2021

Wild-type adenovirus decreases tumor xenograft growth, but despite viral persistence complete tumor responses are rarely achieved--deletion of the viral E1b-19-kD gene increases the viral oncolytic effect

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

7 January 2021

The adenovirus E3-14.7K protein and the E3-10.4K/14.5K complex of proteins, which independently inhibit tumor necrosis factor (TNF)-induced apoptosis, also independently inhibit TNF-induced release of arachidonic acid

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

7 January 2021

Adenovirus E3-10.4K/14.5K protein complex inhibits tumor necrosis factor-induced translocation of cytosolic phospholipase A2 to membranes

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.03.017

7 January 2021

10.1016/J.YMTHE.2004.03.017

Identifiers

DOI

1 reference

21 September 2017

1 reference