The Bcl-2 family member Bfl-1/A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells (Q40566546)

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scientific article published on May 2004

Language	Label	Description	Also known as
English	The Bcl-2 family member Bfl-1/A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells	scientific article published on May 2004

Statements

scholarly article

1 reference

Europe PubMed Central

21 September 2017

The Bcl-2 family member Bfl-1/A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells (English)

1 reference

Europe PubMed Central

21 September 2017

apoptotic process

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author name string

Karin Tarte

1

1 reference

Europe PubMed Central

21 September 2017

Michel Jourdan

2

1 reference

Europe PubMed Central

21 September 2017

Jean Luc Veyrune

3

1 reference

Europe PubMed Central

21 September 2017

Ingolf Berberich

4

1 reference

Europe PubMed Central

21 September 2017

Geneviève Fiol

5

1 reference

Europe PubMed Central

21 September 2017

Nicole Redal

6

1 reference

Europe PubMed Central

21 September 2017

John Shaughnessy

7

1 reference

Europe PubMed Central

21 September 2017

Bernard Klein

8

1 reference

Europe PubMed Central

21 September 2017

language of work or name

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publication date

1 May 2004

1 reference

Europe PubMed Central

21 September 2017

British Journal of Haematology

1 reference

Europe PubMed Central

21 September 2017

125

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Europe PubMed Central

21 September 2017

3

1 reference

Europe PubMed Central

21 September 2017

373-382

1 reference

Europe PubMed Central

21 September 2017

BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone

1 reference

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Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells

1 reference

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22 September 2017

A cellular model for myeloma cell growth and maturation based on an intraclonal CD45 hierarchy

1 reference

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A phase 2 study of bortezomib in relapsed, refractory myeloma

1 reference

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22 September 2017

A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells

1 reference

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22 September 2017

NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1

1 reference

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22 September 2017

Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation

1 reference

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22 September 2017

Regulatory mechanisms that determine the development and function of plasma cells

1 reference

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22 September 2017

Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma

1 reference

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22 September 2017

Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

1 reference

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22 September 2017

Humoral immunity and long-lived plasma cells

1 reference

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22 September 2017

Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells

1 reference

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22 September 2017

Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

1 reference

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22 September 2017

Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications

1 reference

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22 September 2017

The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression

1 reference

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22 September 2017

NF-kappa B as a therapeutic target in multiple myeloma

1 reference

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22 September 2017

Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells

1 reference

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22 September 2017

Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

22 September 2017

BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cells

1 reference

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22 September 2017

Repression of c-myc is necessary but not sufficient for terminal differentiation of B lymphocytes in vitro

1 reference

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22 September 2017

Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

22 September 2017

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

22 September 2017

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1 reference

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22 September 2017

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

22 September 2017

Cluster analysis and display of genome-wide expression patterns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

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Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

22 September 2017

Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1

1 reference

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22 September 2017

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

22 September 2017

Role of NF-kappaB in the rescue of multiple myeloma cells from glucocorticoid-induced apoptosis by bcl-2.

1 reference

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25 September 2017

Functional dissection of Bfl-1, a Bcl-2 homolog: anti-apoptosis, oncogene-cooperation and cell proliferation activities

1 reference

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Isolation, maturational level, and functional capacity of human colon lamina propria plasma cells.

1 reference

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15 June 2018

Long-lived B cells are distinguished by elevated expression of A1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

15 June 2018

Humoral immunity due to long-lived plasma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

15 June 2018

Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

15 June 2018

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

1 reference

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20 August 2018

Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

20 August 2018

An interfering form of Blimp-1 increases IgM secreting plasma cells and blocks maturation of peripheral B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

20 August 2018

Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

20 August 2018

Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

20 August 2018

BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

20 August 2018

Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

20 August 2018

Reversal of Blimp-1-mediated apoptosis by A1, a member of the Bcl-2 family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

20 August 2018

Blimp-1 overcomes the block in IgM secretion in lipopolysaccharide/anti-mu F(ab')2-co-stimulated B lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

20 August 2018

Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

2 December 2018

The CD40-Inducible Bcl-2 Family Member A1 Protects B Cells from Antigen Receptor-Mediated Apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685897

2 December 2018

Human A1 expression in acute myeloid leukemia and its relationship to Bcl-2 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15086420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15086420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/15086420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax

1 reference

https://pubmed.ncbi.nlm.nih.gov/15086420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A1 expression is stimulated by CD40 in B cells and rescues WEHI 231 cells from anti-IgM-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15086420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival of leukemic B cells promoted by engagement of the antigen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15086420

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2141.2004.04908.X

1 reference

Europe PubMed Central

21 September 2017

1 reference

Europe PubMed Central

21 September 2017

1 reference

Europe PubMed Central

21 September 2017

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