Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program (Q28216493)

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Kuo I Lin

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Tracy C Kuo

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Xin Yu

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Elaine M Hurt

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Jena M Giltnane

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Liming Yang

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Hong Zhao

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

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language of work or name

English

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publication date

July 2002

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published in

Immunity

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volume

17

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page(s)

51-62

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issue

1

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cites work

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Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.

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The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP

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Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells

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Molecular definition of the germinal centre stage of B-cell differentiation

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Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

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Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

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Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

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Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis

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BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cells

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Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1

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