Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway (Q40568061)

21 September 2017

Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway (English)

1 reference

21 September 2017

Xiangjun Tong

1

1 reference

21 September 2017

James O'Kelly

2

1 reference

21 September 2017

Dong Xie

3

1 reference

21 September 2017

Akio Mori

4

1 reference

21 September 2017

Nathan Lemp

5

1 reference

21 September 2017

Robert McKenna

6

1 reference

21 September 2017

Carl W Miller

7

1 reference

21 September 2017

H Phillip Koeffler

8

1 reference

21 September 2017

language of work or name

English

0 references

publication date

1 June 2004

1 reference

21 September 2017

1 reference

21 September 2017

23

1 reference

21 September 2017

4847-4855

1 reference

21 September 2017

28

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.onc.1207628

21 September 2017

0 references

cites work

CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

Myc and Max function as a nucleoprotein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

A pure estrogen antagonist inhibits cyclin E-Cdk2 activity in MCF-7 breast cancer cells and induces accumulation of p130-E2F4 complexes characteristic of quiescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

myc function and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

Beta-catenin: a key mediator of Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

Regulation of p53 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

p53-dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Stress signals utilize multiple pathways to stabilize p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Functional interaction of beta-catenin with the transcription factor LEF-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

APC: the plot thickens

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Wnt signaling: a common theme in animal development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Armadillo takes the APC shuttle.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Wingless signaling: the inconvenient complexities of life

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Excess beta-catenin promotes accumulation of transcriptionally active p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

c-Myc target genes involved in cell growth, apoptosis, and metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Induction of apoptosis in fibroblasts by c-myc protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Cell adhesion: the molecular basis of tissue architecture and morphogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Identification of c-MYC as a target of the APC pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Mediation of c-Myc-induced apoptosis by p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Oncogenic forms of p53 inhibit p53-regulated gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

The p53 tumor-suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Principles of CDK regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Expression of the extracellular matrix signaling molecule Cyr61 is downregulated in prostate cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Transactivation of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Cloning of mid-G1 serum response genes and identification of a subset regulated by conditional myc expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Deregulated expression of c-Myc depletes epidermal stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

p21 is a universal inhibitor of cyclin kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207628

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207628

1 reference

Dimensions Publication ID

21 September 2017

0 references

1 reference