iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. (Q40610046)

22 September 2017

title

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. (English)

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22 September 2017

Wei-Wei Luo

1

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22 September 2017

Shu Li

2

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22 September 2017

Chen Li

3

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22 September 2017

Huan Lian

4

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22 September 2017

Qing Yang

5

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22 September 2017

Bo Zhong

6

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22 September 2017

Hong-Bing Shu

7

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22 September 2017

language of work or name

English

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publication date

18 July 2016

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22 September 2017

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22 September 2017

volume

17

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22 September 2017

issue

9

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22 September 2017

page(s)

1057-1066

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Pathogen recognition and innate immunity

22 September 2017

cites work

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Pattern recognition receptors and inflammation

21 January 2018

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Nucleic acid recognition by the innate immune system

21 January 2018

1 reference

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

21 January 2018

1 reference

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

21 January 2018

1 reference

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

21 January 2018

1 reference

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

21 January 2018

1 reference

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

21 January 2018

1 reference

IFI16 is an innate immune sensor for intracellular DNA

21 January 2018

1 reference

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

21 January 2018

1 reference

LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection

21 January 2018

1 reference

21 January 2018

Immune sensing of DNA

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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 January 2018

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Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

21 January 2018

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Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

21 January 2018

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 January 2018

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

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The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

21 January 2018

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The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

21 January 2018

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TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

21 January 2018

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The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

21 January 2018

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The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

21 January 2018

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RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms

21 January 2018

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STING manifests self DNA-dependent inflammatory disease

21 January 2018

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Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

21 January 2018

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Activated STING in a vascular and pulmonary syndrome

21 January 2018

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Rhomboid proteases and their biological functions

21 January 2018

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Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

21 January 2018

1 reference

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

21 January 2018

1 reference

Emerging role of rhomboid family proteins in mammalian biology and disease

21 January 2018

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5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential

21 January 2018

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Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

21 January 2018

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21 January 2018

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

21 January 2018

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Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

21 January 2018

1 reference

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27428826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.3510

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22 September 2017

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