3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro. (Q40632205)

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19 December 2019

title

3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro (English)

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19 December 2019

9

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19 December 2019

Roger M. Phillips

2

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19 December 2019

Christian Cole

5

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19 December 2019

Ian Stratford

8

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19 December 2019

3

Kaye J Williams

1 reference

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19 December 2019

6

Natasha S Wind

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19 December 2019

author name string

Mohammed Jaffar

1

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19 December 2019

Ibrahim Mrema

4

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19 December 2019

Timothy H Ward

7

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19 December 2019

language of work or name

English

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publication date

1 October 2003

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19 December 2019

published in

Biochemical Pharmacology

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19 December 2019

volume

66

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19 December 2019

issue

7

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19 December 2019

page(s)

1199-1206

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Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C

19 December 2019

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Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol

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2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo

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Indolequinone Antitumor Agents: Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro Cytotoxicity1

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Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles: structure-activity relationships for cytotoxicity and antitumor activity

7 January 2021

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Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones

7 January 2021

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NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms

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Structure-function studies of DT-diaphorase (NQO1) and NRH: quinone oxidoreductase (NQO2).

7 January 2021

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The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions

7 January 2021

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Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

7 January 2021

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Prodrugs for targeting hypoxic tissues: regiospecific elimination of aspirin from reduced indolequinones

7 January 2021

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Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.

7 January 2021

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Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase

7 January 2021

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Expression of rat liver NAD(P)H:quinone-acceptor oxidoreductase in Escherichia coli and mutagenesis in vitro at Arg-177

7 January 2021

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Development of a bicistronic vector driven by the human polypeptide chain elongation factor 1alpha promoter for creation of stable mammalian cell lines that express very high levels of recombinant proteins

7 January 2021

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Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.

7 January 2021

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Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

7 January 2021

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Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

7 January 2021

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The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay

7 January 2021

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Comet assay studies on the activation of two diaziridinylbenzoquinones in K562 cells

7 January 2021

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Indolequinone antitumor agents: Relationship between quinone structure and rate of metabolism by recombinant human NQO1

7 January 2021

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Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism

7 January 2021

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Structure-Based Development of Anticancer Drugs

7 January 2021

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Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.

7 January 2021

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Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase

7 January 2021

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Design, synthesis, and biological evaluation of indolequinone phosphoramidate prodrugs targeted to DT-diaphorase

7 January 2021

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Development of novel quinone phosphorodiamidate prodrugs targeted to DT-diaphorase

7 January 2021

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10.1016/S0006-2952(03)00452-0

7 January 2021

Identifiers

DOI

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release_wihv3qxtlnhubjs6lbrjqqlnlq

19 December 2019

Fatcat ID

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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