Membrane topology of gamma-secretase component PEN-2. (Q40663628)

22 September 2017

title

Membrane topology of gamma-secretase component PEN-2. (English)

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22 September 2017

3

Theodore C Pierson

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22 September 2017

Adam S Crystal

1

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author name string

Vanessa A Morais

2

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22 September 2017

Donald S Pijak

4

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22 September 2017

Dan Carlin

5

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22 September 2017

Virginia M-Y Lee

6

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22 September 2017

Robert W Doms

7

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22 September 2017

language of work or name

English

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publication date

14 March 2003

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Journal of Biological Chemistry

22 September 2017

number of pages

7

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based on heuristic

inferred from page(s)

published in

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22 September 2017

volume

278

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22 September 2017

issue

22

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22 September 2017

page(s)

20117-20123

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Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

22 September 2017

cites work

1 reference

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

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PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

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The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

21 January 2018

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

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Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

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PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

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Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

21 January 2018

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Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

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Assembly of asparagine-linked oligosaccharides

21 January 2018

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Subcellular distribution and membrane topology of the mammalian concentrative Na+-nucleoside cotransporter rCNT1.

21 January 2018

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The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry.

21 January 2018

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

21 January 2018

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Calnexin: a membrane-bound chaperone of the endoplasmic reticulum

21 January 2018

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Characterization of a cis-Golgi matrix protein, GM130

21 January 2018

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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

21 January 2018

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

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Processing of N-linked oligosaccharide depends on its location in the anion exchanger, AE1, membrane glycoprotein

21 January 2018

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Protein topology of presenilin 1

21 January 2018

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Membrane topology of the C. elegans SEL-12 presenilin

21 January 2018

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Membrane topology of Alzheimer's disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure

21 January 2018

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Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M213107200

1 reference

22 September 2017

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