Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling (Q34810184)

4 August 2017

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title

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling (English)

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4 August 2017

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Mark E Fortini

1

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4 August 2017

1 September 2002

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Nature Reviews Molecular Cell Biology

4 August 2017

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4 August 2017

3

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4 August 2017

673-684

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4 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrm910

4 August 2017

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cites work

Notch signaling: cell fate control and signal integration in development

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Notch and presenilin: a proteolytic mechanism emerges

31 March 2020

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A common enzyme connects notch signaling and Alzheimer's disease

31 March 2020

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Notch signal transduction: a real rip and more

31 March 2020

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LIN-12/Notch signaling: lessons from worms and flies

31 March 2020

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Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats

31 March 2020

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Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors

31 March 2020

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31 March 2020

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Structure/function studies of lin-12/Notch proteins.

31 March 2020

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The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

31 March 2020

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

31 March 2020

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Presenilins and the intramembrane proteolysis of proteins: facts and fiction.

31 March 2020

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Translating cell biology into therapeutic advances in Alzheimer's disease

31 March 2020

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Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

31 March 2020

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

31 March 2020

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Protein topology of presenilin 1

31 March 2020

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Membrane topology of the C. elegans SEL-12 presenilin

31 March 2020

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Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

31 March 2020

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Characterization of Drosophila Presenilin and its colocalization with Notch during development.

31 March 2020

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Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

31 March 2020

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Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

31 March 2020

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PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling

31 March 2020

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Absence of endoproteolysis but no effects on amyloid beta production by alternative splicing forms of presenilin-1, which lack exon 8 and replace D257A.

31 March 2020

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Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

31 March 2020

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Endoproteolytic processing and stabilization of wild-type and mutant presenilin

31 March 2020

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

31 March 2020

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

31 March 2020

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

31 March 2020

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Nicastrin binds to membrane-tethered Notch

31 March 2020

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

31 March 2020

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Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

31 March 2020

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Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

31 March 2020

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Drosophila nicastrin is essential for the intramembranous cleavage of notch

31 March 2020

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APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

31 March 2020

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

31 March 2020

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

31 March 2020

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

31 March 2020

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Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

31 March 2020

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Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana

31 March 2020

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Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

31 March 2020

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

31 March 2020

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Effects of PS1 deficiency on membrane protein trafficking in neurons.

31 March 2020

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Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

31 March 2020

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

31 March 2020

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

31 March 2020

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Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

31 March 2020

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Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

31 March 2020

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Presenilin is required for activity and nuclear access of Notch in Drosophila

31 March 2020

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Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

31 March 2020

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Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

31 March 2020

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Skeletal and CNS defects in Presenilin-1-deficient mice

31 March 2020

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Mice lacking both presenilin genes exhibit early embryonic patterning defects

31 March 2020

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

31 March 2020

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Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

31 March 2020

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Lack of requirement for presenilin1 in Notch1 signaling.

31 March 2020

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Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

31 March 2020

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

31 March 2020

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Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

31 March 2020

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Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons

31 March 2020

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Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

31 March 2020

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Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

31 March 2020

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Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

31 March 2020

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A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

31 March 2020

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Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans

31 March 2020

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Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

31 March 2020

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Identification and characterization of presenilin-independent Notch signaling

31 March 2020

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Presenilins are not required for A beta 42 production in the early secretory pathway.

31 March 2020

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Notch receptor cleavage depends on but is not directly executed by presenilins

31 March 2020

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

31 March 2020

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Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

31 March 2020

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gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

31 March 2020

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Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

31 March 2020

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Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

31 March 2020

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Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

31 March 2020

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

31 March 2020

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A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

31 March 2020

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Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

31 March 2020

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The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain

31 March 2020

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Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides

31 March 2020

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Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase

31 March 2020

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New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

31 March 2020

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Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

31 March 2020

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The Notch1 receptor is cleaved constitutively by a furin-like convertase

31 March 2020

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Calcium depletion dissociates and activates heterodimeric notch receptors

31 March 2020

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KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis.

31 March 2020

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Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

31 March 2020

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kuzbanian-mediated cleavage of Drosophila Notch

31 March 2020

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A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

31 March 2020

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

31 March 2020

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Requirement for dynamin during Notch signaling in Drosophila neurogenesis.

31 March 2020

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Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function

31 March 2020

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Ligand-induced signaling in the absence of furin processing of Notch1.

31 March 2020

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Furin cleavage is not a requirement for Drosophila Notch function

31 March 2020

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Presenilins: molecular switches between proteolysis and signal transduction

31 March 2020

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The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

31 March 2020

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Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

31 March 2020

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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

31 March 2020

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Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

31 March 2020

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Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

31 March 2020

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

31 March 2020

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

31 March 2020

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The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

31 March 2020

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The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

31 March 2020

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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

31 March 2020

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The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

31 March 2020

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A multi-talented secreted protein

31 March 2020

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

31 March 2020

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Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

31 March 2020

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Untangling the ErbB signalling network

31 March 2020

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Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4

31 March 2020

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Constitutive proteolysis of the ErbB-4 receptor tyrosine kinase by a unique, sequential mechanism.

31 March 2020

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Nuclear localization of EGF receptor and its potential new role as a transcription factor

31 March 2020

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Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

31 March 2020

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Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

31 March 2020

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CD44: structure, function, and association with the malignant process.

31 March 2020

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Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the Rho family of small G proteins.

31 March 2020

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Proteolytic cleavage of the CD44 adhesion molecule in multiple human tumors

31 March 2020

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Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration

31 March 2020

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CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration

31 March 2020

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The Role of presenilins in gamma-secretase activity

31 March 2020

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Regulated intramembrane proteolysis takes another twist

31 March 2020

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Identification of signal peptide peptidase, a presenilin-type aspartic protease

31 March 2020

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

31 March 2020

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Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

31 March 2020

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

31 March 2020

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Identification of a novel family of presenilin homologues

31 March 2020

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Control of EGF receptor activation in Drosophila

31 March 2020

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A thousand and one roles for the Drosophila EGF receptor

31 March 2020

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Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

31 March 2020

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Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

31 March 2020

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Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz

31 March 2020

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Providencia may help find a function for a novel, widespread protein family

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM910

1 reference

PubMed ID

12209127

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

12209127