Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program (Q40715731)

23 September 2017

Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program (English)

1 reference

23 September 2017

1 reference

Louie Lamorte

1

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23 September 2017

Sonia Rodrigues

series ordinal

2

1 reference

23 September 2017

Monica Naujokas

series ordinal

3

1 reference

23 September 2017

Morag Park

series ordinal

4

1 reference

23 September 2017

language of work or name

English

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publication date

23 July 2002

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Journal of Biological Chemistry

23 September 2017

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23 September 2017

277

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23 September 2017

37904-37911

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23 September 2017

40

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23 September 2017

Epithelial morphogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Molecular cloning and expression of human hepatocyte growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Scatter factor induces blood vessel formation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Differential effects of EGF and amphiregulin on adhesion molecule expression and migration of colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Gab3, a new DOS/Gab family member, facilitates macrophage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Crk family adaptors-signalling complex formation and biological roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Motility and invasion are differentially modulated by Rho family GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Physiological signals and oncogenesis mediated through Crk family adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Activation of Rac1 by a Crk SH3-binding protein, DOCK180

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

v-Crk modulation of growth factor-induced PC12 cell differentiation involves the Src homology 2 domain of v-Crk and sustained activation of the Ras/mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Hepatocyte growth factor induces tubulogenesis of primary renal proximal tubular epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

Rac1 mediates type I collagen-dependent MMP-2 activation. role in cell invasion across collagen barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201743200

21 January 2018

Identifiers

DOI

10.1074/JBC.M201743200

1 reference

23 September 2017

1 reference