Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway (Q40729554)

23 September 2017

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway (English)

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23 September 2017

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4

Gregg L Semenza

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23 September 2017

Caroline Treins

1

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23 September 2017

Sophie Giorgetti-Peraldi

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2

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23 September 2017

Joseph Murdaca

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3

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23 September 2017

Emmanuel Van Obberghen

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5

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23 September 2017

language of work or name

English

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publication date

24 May 2002

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Journal of Biological Chemistry

23 September 2017

7

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inferred from page(s)

published in

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23 September 2017

277

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23 September 2017

31

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23 September 2017

27975-27981

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Regulation of vascular endothelial growth factor expression by advanced glycation end products

23 September 2017

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Perspective: The insulin signaling system--a common link in the pathogenesis of type 2 diabetes

21 January 2018

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Insulin signaling pathways in time and space.

21 January 2018

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Surfing the insulin signaling web

21 January 2018

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Insulin signalling and the regulation of glucose and lipid metabolism

21 January 2018

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Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin.

21 January 2018

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Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt

21 January 2018

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Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox

21 January 2018

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Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells.

21 January 2018

1 reference

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Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia.

21 January 2018

1 reference

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Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology

21 January 2018

1 reference

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Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways.

21 January 2018

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Regulation of vascular endothelial growth factor expression by insulin-like growth factor I.

21 January 2018

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Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1.

21 January 2018

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Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes

21 January 2018

1 reference

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HIF-1: mediator of physiological and pathophysiological responses to hypoxia

21 January 2018

1 reference

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

21 January 2018

1 reference

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Role of translocation in the activation and function of protein kinase B

21 January 2018

1 reference

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Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes

21 January 2018

1 reference

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

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Purification and characterization of hypoxia-inducible factor 1

21 January 2018

1 reference

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

21 January 2018

1 reference

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

1 reference

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Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

21 January 2018

1 reference

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Blood glucose concentrations and progression of diabetic retinopathy: the seven year results of the Oslo study

21 January 2018

1 reference

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Association of blindness to intensification of glycemic control in insulin-dependent diabetes mellitus

21 January 2018

1 reference

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Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

21 January 2018

1 reference

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 January 2018

1 reference

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

1 reference

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p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 January 2018

1 reference

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ERK activation upon hypoxia: involvement in HIF-1 activation

21 January 2018

1 reference

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Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

21 January 2018

1 reference

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Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

21 January 2018

1 reference

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Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)

21 January 2018

1 reference

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The mRNA 5' cap-binding protein eIF4E and control of cell growth

21 January 2018

1 reference

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PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation

21 January 2018

1 reference

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Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

21 January 2018

1 reference

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Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin

21 January 2018

1 reference

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Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3-kinase

21 January 2018

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Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.

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Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity

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Stimulation and inhibition of angiogenesis in diabetic retinopathy

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Irreversible progression of severe retinopathy in young type I insulin-dependent diabetes mellitus patients after improved metabolic control

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Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes

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Hypoxia-inducible factor 1: master regulator of O2 homeostasis

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Vascular endothelial growth factor upregulation in human central retinal vein occlusion

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Identifiers

DOI

10.1074/JBC.M204152200

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23 September 2017

1 reference