The Ras signal transduction pathway (Q40733281)

23 September 2017

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title

The Ras signal transduction pathway (English)

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23 September 2017

R Khosravi-Far

1

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PubMed ID

8143346

23 September 2017

C J Der

series ordinal

2

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23 September 2017

1 March 1994

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Cancer and Metastasis Reviews

23 September 2017

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23 September 2017

13

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23 September 2017

1

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23 September 2017

67-89

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https://scigraph.springernature.com/pub.10.1007/bf00690419

23 September 2017

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cites work

Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

1 reference

https://api.crossref.org/works/10.1007%2FBF00690419

Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00690419

Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00690419

Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00690419

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00690419

Growth-regulated expression of rhoG, a new member of the ras homolog gene family

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00690419

Characterization and expression of the human rhoH12 gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00690419

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00690419

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

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12 December 2020

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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12 December 2020

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12 December 2020

Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator

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12 December 2020

Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors

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12 December 2020

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase

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12 December 2020

Cellular ras activity and tumor cell proliferation

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12 December 2020

The ras protein family: evolutionary tree and role of conserved amino acids

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12 December 2020

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

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12 December 2020

Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein

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12 December 2020

Increased levels of p21ras-GTP and enhanced DNA synthesis accompany elevated tyrosyl phosphorylation of GAP-associated proteins, p190 and p62, in c-src overexpressors.

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12 December 2020

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12 December 2020

Role of the C-terminal region of smg p25A in its interaction with membranes and the GDP/GTP exchange protein

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12 December 2020

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.

1 reference

12 December 2020

Isolation of a new human oncogene from a diffuse B-cell lymphoma.

1 reference

12 December 2020

ras GTPase activating protein: signal transmitter and signal terminator

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12 December 2020

Tumorigenic activity of rho genes from Aplysia californica

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12 December 2020

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

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12 December 2020

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

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12 December 2020

Function of Ras as a molecular switch in signal transduction

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12 December 2020

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

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12 December 2020

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases

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12 December 2020

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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12 December 2020

A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila

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12 December 2020

Transgenic models of tumor development.

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12 December 2020

GAP as ras effector or negative regulator?

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12 December 2020

Activation of mitogen-activated protein (MAP) kinase by a MAP kinase-kinase

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12 December 2020

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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12 December 2020

Differential regulation of rasGAP and neurofibromatosis gene product activities

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12 December 2020

Transforming and c-fos promoter/enhancer-stimulating activities of a stimulatory GDP/GTP exchange protein for small GTP-binding proteins

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12 December 2020

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12 December 2020

Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation

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12 December 2020

Protein prenylation: more than just glue?

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12 December 2020

Raf functions downstream of Ras1 in the Sevenless signal transduction pathway

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12 December 2020

Identification of a nucleotide exchange-promoting activity for p21ras

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12 December 2020

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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12 December 2020

Somatic mutations in the neurofibromatosis 1 gene in human tumors

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12 December 2020

Activation of Ras by insulin in 3T3 L1 cells does not involve GTPase-activating protein phosphorylation

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12 December 2020

The Son of sevenless Gene Product: a Putative Activator of Ras

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12 December 2020

The many roads that lead to Ras.

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12 December 2020

Exchange rate mechanisms

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12 December 2020

Emerging concepts in the Ras superfamily of GTP-binding proteins.

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12 December 2020

Suppression of c-ras transformation by GTPase-activating protein

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12 December 2020

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

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12 December 2020

A cytoplasmic protein inhibits the GTPase activity of H-Ras in a phospholipid-dependent manner

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12 December 2020

The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17.

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12 December 2020

Saccharomyces cerevisiae CDC25 (1028-1589) is a guanine nucleotide releasing factor for mammalian ras proteins and is oncogenic in NIH3T3 cells.

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12 December 2020

Regulators and Effectors of ras Proteins

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12 December 2020

A signal chain of events

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12 December 2020

Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP-mediated signaling

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12 December 2020

A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins.

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12 December 2020

Quantitative analysis of SH2 domain binding. Evidence for specificity and competition

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12 December 2020

Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6, induce an accumulation of an active Ras.GTP complex in rat pheochromocytoma PC12 cells

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12 December 2020

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product

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12 December 2020

MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts

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12 December 2020

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells

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12 December 2020

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

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12 December 2020

Ras in signal transduction

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12 December 2020

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein

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12 December 2020

Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor.

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12 December 2020

Homologous activators of ras in fission and budding yeast

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12 December 2020

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

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12 December 2020

Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae

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12 December 2020

Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH 3T3 and rat 1a cells

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12 December 2020

A ras effector domain mutant which is temperature sensitive for cellular transformation: interactions with GTPase-activating protein and NF-1

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12 December 2020

Activation of p21ras by transforming growth factor beta in epithelial cells

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12 December 2020

GTPase activating proteins

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12 December 2020

Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association

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12 December 2020

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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12 December 2020

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12 December 2020

Binding of GAP to activated PDGF receptors

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12 December 2020

Nerve growth factor stimulation of the Ras-guanine nucleotide exchange factor and GAP activities

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12 December 2020

The GTPase superfamily: a conserved switch for diverse cell functions

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12 December 2020

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP

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12 December 2020

Erks: their fifteen minutes has arrived

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12 December 2020

Stimulation of p21 ras upon T-cell activation

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12 December 2020

Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheochromocytoma PC12 cells.

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12 December 2020

Ras regulation. NF is enough of GAP

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12 December 2020

Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids

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12 December 2020

Signal transduction. How receptors turn Ras on.

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12 December 2020

Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions

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12 December 2020

Signal transduction through small GTPases—A tale of two GAPs

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12 December 2020

The mitogen-activated protein kinase activator

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12 December 2020

FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1.

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12 December 2020

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

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12 December 2020

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells

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12 December 2020

Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/"effector" domain

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12 December 2020

PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

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12 December 2020

A conserved kinase cascade for MAP kinase activation in yeast.

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12 December 2020

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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12 December 2020

Regulation of ras p21 by GTPase Activating Proteins

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12 December 2020

Molecular cloning of two types of GAP complementary DNA from human placenta

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12 December 2020

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

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12 December 2020

Ras C-terminal processing enzymes--new drug targets?

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12 December 2020

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

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12 December 2020

Implication of GAP in Ras-dependent transactivation of a polyoma enhancer sequence

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12 December 2020

RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway.

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12 December 2020

Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus

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12 December 2020

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

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12 December 2020

Signal transduction and the fate of the R7 photoreceptor in Drosophila

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12 December 2020

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro

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12 December 2020

Cellular ras activity and phospholipid metabolism

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12 December 2020

Triggering signaling cascades by receptor tyrosine kinases

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12 December 2020

The GTPase superfamily: conserved structure and molecular mechanism

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12 December 2020

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12 December 2020

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

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12 December 2020

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase

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12 December 2020

Cloning of bovine GAP and its interaction with oncogenic ras p21.

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12 December 2020

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

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12 December 2020

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

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12 December 2020

ras oncogenes in human cancer: a review

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12 December 2020

A cytosolic protein catalyzes the release of GDP from p21ras

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12 December 2020

Regulation of p21ras activity

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12 December 2020

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

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12 December 2020

Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase

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12 December 2020

The target sets the tempo

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12 December 2020

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

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12 December 2020

Bcr encodes a GTPase-activating protein for p21rac

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12 December 2020

Posttranslational modification of proteins by isoprenoids in mammalian cells

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12 December 2020

Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24

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12 December 2020

Microinjection of recombinant p21rho induces rapid changes in cell morphology

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12 December 2020

Signal transduction during C. elegans vulval induction

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12 December 2020

The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes

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12 December 2020

The Role of Raf-1 Phosphorylation in Signal Transduction

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12 December 2020

ADP-ribosylation by Clostridium botulinum C3 exoenzyme increases steady-state GTPase activities of recombinant rhoA and rhoB proteins

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12 December 2020

Non-nuclear oncogenes and the regulation of gene expression in transformed cells.

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12 December 2020

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

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12 December 2020

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein

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12 December 2020

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

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12 December 2020

Signal transduction within the nucleus by mitogen-activated protein kinase

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12 December 2020

Oncogene ect2 is related to regulators of small GTP-binding proteins

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12 December 2020

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

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12 December 2020

Kinase cascade conserved

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12 December 2020

Raf-1 activates MAP kinase-kinase

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12 December 2020

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

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12 December 2020

Post-translational modifications of p21rho proteins

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12 December 2020

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

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12 December 2020

Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.

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12 December 2020

Protein prenylation: key to ras function and cancer intervention?

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12 December 2020

Eye development. Function for Ras in sight.

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12 December 2020

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

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12 December 2020

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.

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12 December 2020

GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion

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12 December 2020

Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras

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12 December 2020

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity

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12 December 2020

NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation

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12 December 2020

ras activation in experimental carcinogenesis.

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12 December 2020

SH2 and SH3 domains: from structure to function

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12 December 2020

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12 December 2020

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

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12 December 2020

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product.

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12 December 2020

Identification of a ten-amino acid proline-rich SH3 binding site

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12 December 2020

Missing links between receptors and Ras.

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12 December 2020

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

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12 December 2020

ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels

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12 December 2020

Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells

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12 December 2020

Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells

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12 December 2020

Small GTP-binding proteins

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12 December 2020

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

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12 December 2020

Plasma membrane-targeted ras GTPase-activating protein is a potent suppressor of p21ras function

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12 December 2020

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

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12 December 2020

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway.

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12 December 2020

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

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12 December 2020

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

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12 December 2020

Requirement for c-ras proteins during viral oncogene transformation

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12 December 2020

Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells

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12 December 2020

Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines

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12 December 2020

CD2 antigen mediated activation of the guanine nucleotide binding proteins p21ras in human T lymphocytes

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12 December 2020

The Saccharomyces cerevisiae gene product SDC25 C-domain functions as an oncoprotein in NIH3T3 cells.

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12 December 2020

The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.

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12 December 2020

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4

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12 December 2020

Ras p21: effects and regulation

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12 December 2020

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12 December 2020

Regulatory mechanisms for ras proteins

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12 December 2020

The ras superfamily of GTP-binding proteins: guidelines on nomenclature

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12 December 2020

Characterization of downstream elements in a Raf-1 pathway

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12 December 2020

MAP kinase by any other name smells just as sweet

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12 December 2020

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

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12 December 2020

Insulin stimulation of gene expression mediated by p21ras activation.

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12 December 2020

The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression

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12 December 2020

GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents

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12 December 2020

Phosphorylation of c-jun mediated by MAP kinases.

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12 December 2020

The ABL-BCR fusion gene is expressed in chronic myeloid leukemia

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12 December 2020

Signalling through SH2 and SH3 domains

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12 December 2020

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

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12 December 2020

NF1: a prevalent cause of tumorigenesis in human cancers?

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12 December 2020

A putative modular domain present in diverse signaling proteins

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12 December 2020

New intracellular targets for therapeutic drug design

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12 December 2020

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

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12 December 2020

The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization

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12 December 2020

Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins.

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12 December 2020

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation

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12 December 2020

Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients

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12 December 2020

Neurofibromatosis type 1 gene mutations in neuroblastoma

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12 December 2020

Src homology region 2 domains direct protein-protein interactions in signal transduction

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12 December 2020

Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase

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12 December 2020

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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12 December 2020

MAP kinase regulation--the oncogene connection

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12 December 2020

Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

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12 December 2020

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity

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12 December 2020

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

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12 December 2020

Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein

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12 December 2020

Identifiers

DOI

10.1007/BF00690419

1 reference

PubMed ID

8143346

Dimensions Publication ID

23 September 2017

0 references

1 reference

PubMed ID

8143346