PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy (Q40765673)

23 September 2017

PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy (English)

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23 September 2017

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2

Jack E Dixon

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23 September 2017

Lindsey D Mayo

1

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23 September 2017

Donald L Durden

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3

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23 September 2017

Nickolas K Tonks

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4

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23 September 2017

David B Donner

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5

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23 September 2017

language of work or name

English

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publication date

29 November 2001

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Journal of Biological Chemistry

23 September 2017

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23 September 2017

277

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23 September 2017

5484-5489

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23 September 2017

7

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

23 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Induction of NF-kappaB by the Akt/PKB kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

p53, the cellular gatekeeper for growth and division

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

Mechanisms of p53-mediated apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

Functions of the MDM2 oncoprotein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

Mapping of the p53 and mdm-2 interaction domains

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

Regulation of p53 stability by Mdm2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

PTEN controls tumor-induced angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

PTEN: sometimes taking it off can be better than putting it on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Interleukin 3-dependent survival by the Akt protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Akt signaling: linking membrane events to life and death decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M108302200

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Presence of a potent transcription activating sequence in the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

Restoration of wild-type PTEN expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108302200

21 January 2018

Identifiers

DOI

10.1074/JBC.M108302200

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23 September 2017

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