The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo (Q40772958)

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English	The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

23 September 2017

The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo (English)

1 reference

Europe PubMed Central

23 September 2017

author name string

Andreasson P

1

1 reference

Europe PubMed Central

23 September 2017

Schwaller J

2

1 reference

Europe PubMed Central

23 September 2017

Anastasiadou E

3

1 reference

Europe PubMed Central

23 September 2017

Aster J

4

1 reference

Europe PubMed Central

23 September 2017

Gilliland DG

5

1 reference

Europe PubMed Central

23 September 2017

publication date

1 October 2001

1 reference

Europe PubMed Central

23 September 2017

Cancer Genetics and Cytogenetics

1 reference

Europe PubMed Central

23 September 2017

130

1 reference

Europe PubMed Central

23 September 2017

2

1 reference

Europe PubMed Central

23 September 2017

93-104

1 reference

Europe PubMed Central

23 September 2017

TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The TEL gene contributes to the pathogenesis of myeloid and lymphoid leukemias by diverse molecular genetic mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The TEL gene products: nuclear phosphoproteins with DNA binding properties

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a role of NF-kappaB in the survival of hematopoietic cells mediated by interleukin 3 and the oncogenic TEL/platelet-derived growth factor receptor beta fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Haemopoietic transformation by the TEL/ABL oncogene.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

ETS-core binding factor: a common composite motif in antigen receptor gene enhancers

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The AML1/ETO fusion protein activates transcription of BCL-2

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The Runt domain identifies a new family of heteromeric transcriptional regulators.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

ETV6 is the target of chromosome 12p deletions in t(12;21) childhood acute lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of TEL proteins in human leukemias

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22)

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Murine interleukin 7 (IL-7) receptor. Characterization on an IL-7-dependent cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Acute leukaemia in bcr/abl transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Introduction of a mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

B-cell development: a comparison between mouse and man.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The distribution of CD10 (NEP 24.11, CALLA) in humans and mice is similar in non-lymphoid organs but differs within the hematopoietic system: absence on murine T and B lymphoid progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Translocations, master genes, and differences between the origins of acute and chronic leukemias

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0165-4608%2801%2900518-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0165-4608(01)00518-0

1 reference

Europe PubMed Central

23 September 2017

1 reference

Europe PubMed Central

23 September 2017

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