A melanoma-associated germline mutation in exon 1beta inactivates p14ARF. (Q40778590)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

A melanoma-associated germline mutation in exon 1beta inactivates p14ARF (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Helen Rizos

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Celia Badenas

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Josep Malvehy

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Montserrat Milà

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Richard F. Kefford

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

author name string

Darmanian AP

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Jiménez L

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

language of work or name

English

0 references

publication date

1 September 2001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

volume

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

issue

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

page(s)

5543-5547

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/sj.onc.1204728

11 November 2019

exact match

0 references

cites work

Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Human ARF binds E2F1 and inhibits its transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Mdm2 association with p53 targets its ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Selective deletion of exon 1 beta of the p19ARF gene in metastatic melanoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

p19ARF targets certain E2F species for degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Incidence of p14ARF gene deletion in high-grade adult and pediatric astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Differential expression of p16INK4a and p16beta transcripts in B-lymphoblastoid cells from members of hereditary melanoma families without CDKN2A exon mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

p53-independent role of MDM2 in TGF-beta1 resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

7 January 2021

Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

7 January 2021

Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

7 January 2021

Haplotype analysis of two recurrentCDKN2A mutations in 10 melanoma families: Evidence for common founders and independent mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

7 January 2021

Multiple abnormalities of the p16INK4a-pRb regulatory pathway in cultured melanoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

7 January 2021

Retention of theCDKN2A locus and low frequency of point mutations in primary and metastasic cutaneous malignant melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

7 January 2021

Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204728

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204728

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11571653%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 November 2019

0 references

1 reference