alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells. (Q40794684)

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English	alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells.	scientific article

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23 September 2017

alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells (English)

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12 May 2020

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C Hall

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G J Michael

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N Cann

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G Ferrari

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M Teo

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T Jacobs

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C Monfries

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L Lim

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publication date

1 July 2001

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23 September 2017

Journal of Neuroscience

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12 May 2020

21

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14

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12 May 2020

5191-5202

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12 May 2020

Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42.

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https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

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inferred from PubMed ID database lookup

The structure of the GTPase-activating domain from p50rhoGAP

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https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33

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https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho.

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https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical studies of the mechanism of action of the Cdc42-GTPase-activating protein

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https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eph receptors and ephrins in neural development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early postmitotic neurons transiently express TOAD-64, a neural specific protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PAK promotes morphological changes by acting upstream of Rac.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rac1 mediates collapsin-1-induced growth cone collapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diversity and versatility of GTPase activating proteins for the p21rho subfamily of ras G proteins detected by a novel overlay assay.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memory-related neural systems in Alzheimer's disease: an anatomic study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct patterns of expression of different protein kinase C mRNAs in rat tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breakpoint cluster region gene product-related domain of n-chimaerin. Discrimination between Rac-binding and GTPase-activating residues by mutational analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Single Point Mutation Switches the Specificity of Group III Src Homology (SH) 2 Domains to That of Group I SH2 Domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel disruption of cortical development in p35(-/-) mice distinct from reeler

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A family of rat CRMP genes is differentially expressed in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ontogeny of Neurochemical Markers for Noradrenergic, GABAergic and Cholinergic Neurons in Neocortex Lesioned with Methylazoxymethanol Acetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of a family of muscarinic receptor mRNAs in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcr encodes a GTPase-activating protein for p21rac

1 reference

https://pubmed.ncbi.nlm.nih.gov/11438594

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-14-05191.2001

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762853&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762853&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762853&resulttype=core&format=json

12 May 2020

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