Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines (Q40800443)

23 September 2017

title

Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines (English)

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23 September 2017

Satoh J

1

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23 September 2017

Kuroda Y

series ordinal

2

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23 September 2017

publication date

1 June 2001

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23 September 2017

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23 September 2017

volume

21

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23 September 2017

issue

2

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23 September 2017

page(s)

115-122

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Translating cell biology into therapeutic advances in Alzheimer's disease

23 September 2017

cites work

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

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Presenilin is required for activity and nuclear access of Notch in Drosophila

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Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

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Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

21 January 2018

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Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

21 January 2018

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BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

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Brain-derived neurotrophic factor is reduced in Alzheimer's disease

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Differential gene expression between human neurons and neuronal progenitor cells in culture: an analysis of arrayed cDNA clones in NTera2 human embryonal carcinoma cell line as a model system

21 January 2018

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Constitutive and cytokine-inducible expression of prion protein gene in human neural cell lines

21 January 2018

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Beta-catenin expression in human neural cell lines following exposure to cytokines and growth factors.

21 January 2018

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Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors.

21 January 2018

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Alpha-synuclein expression is up-regulated in NTera2 cells during neuronal differentiation but unaffected by exposure to cytokines and neurotrophic factors

21 January 2018

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Hematolymphopoietic and inflammatory cytokines in neural development

21 January 2018

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10.1046/J.1440-1789.2001.00378.X

21 January 2018

Identifiers

DOI

1 reference

23 September 2017

1 reference