Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV. (Q40810916)

23 September 2017

Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV. (English)

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23 September 2017

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L J Bean

1

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23 September 2017

G R Stark

series ordinal

2

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23 September 2017

language of work or name

English

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publication date

1 March 2001

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23 September 2017

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23 September 2017

20

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23 September 2017

9

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23 September 2017

1076-1084

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204204

23 September 2017

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1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Regulation of p53 function and stability by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

DNA-dependent protein kinase-independent activation of p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

A DNA-activated protein kinase from HeLa cell nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Stabilization and activation of p53 are regulated independently by different phosphorylation events

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

MEKK1/JNK signaling stabilizes and activates p53.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

JNK targets p53 ubiquitination and degradation in nonstressed cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Small peptides activate the latent sequence-specific DNA binding function of p53.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

That BLUP is a Good Thing: The Estimation of Random Effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Phosphorylation sites in the amino-terminal region of mouse p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

7 January 2021

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

7 January 2021

Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

7 January 2021

Synergistic activation of transcription by CBP and p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

7 January 2021

Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204204

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204204

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Dimensions Publication ID

23 September 2017

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