Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1. (Q40881378)

24 September 2017

Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1. (English)

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24 September 2017

Verdile G

1

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24 September 2017

Martins RN

2

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24 September 2017

Duthie M

3

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24 September 2017

Holmes E

4

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24 September 2017

St George-Hyslop PH

5

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24 September 2017

Fraser PE

6

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24 September 2017

language of work or name

English

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publication date

1 July 2000

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Journal of Biological Chemistry

24 September 2017

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24 September 2017

275

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24 September 2017

27

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24 September 2017

20794-20798

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https://api.crossref.org/works/10.1074%2FJBC.C000208200

24 September 2017

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Biology of presenilins as causative molecules for Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Presenilin 1 binds to amyloid precursor protein directly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Presenilin 1 is actively degraded by the 26S proteasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Evidence for lysosomal processing of amyloid beta-protein precursor in cultured cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Proteasome inhibitors induce the association of Alzheimer's amyloid precursor protein with Hsc73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-beta precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

Lack of interactions between amyloid precursor protein and hydrophilic domains of presenilin 1 and 2 using the yeast two hybrid system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

RAP, a novel type of ER chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000208200

21 January 2018

Identifiers

DOI

10.1074/JBC.C000208200

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24 September 2017

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