LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1. (Q40969353)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15181175%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1 (English)

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29 December 2019

1

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29 December 2019

Jean-Jacques Toulmé

5

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29 December 2019

author name string

Jens Bo Hansen

2

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29 December 2019

Henrik Orum

3

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29 December 2019

Carmelo Di Primo

4

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29 December 2019

publication date

4 June 2004

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29 December 2019

published in

Nucleic Acids Research

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29 December 2019

volume

32

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29 December 2019

issue

10

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29 December 2019

page(s)

3101-3107

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Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication

29 December 2019

cites work

1 reference

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Molecular dynamics reveals the stabilizing role of loop closing residues in kissing interactions: comparison between TAR-TAR* and TAR-aptamer

25 September 2017

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Interactions of Hairpin Oligo-2′-O-Methylribonucleotides Containing Methylphosphonate Linkages with HIV TAR RNA

25 September 2017

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25 September 2017

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In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides

25 September 2017

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Single nucleotide polymorphism genotyping using locked nucleic acid (LNA).

25 September 2017

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Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design

25 September 2017

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RNA as a target for drug design, the example of Tat-TAR interaction.

25 September 2017

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Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing

25 September 2017

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Loop-loop interaction of HIV-1 TAR RNA with N3'-->P5' deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription

25 September 2017

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Structure of TAR RNA complexed with a Tat-TAR interaction nanomolar inhibitor that was identified by computational screening

25 September 2017

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siRNA-directed inhibition of HIV-1 infection

25 September 2017

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Design and characterization of decoy oligonucleotides containing locked nucleic acids

25 September 2017

1 reference

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Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids

25 September 2017

1 reference

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Design of antisense oligonucleotides stabilized by locked nucleic acids

25 September 2017

1 reference

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Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA.

25 September 2017

1 reference

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Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2'-O-methyl/LNA oligoribonucleotides.

25 September 2017

1 reference

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Application of PNA and LNA oligomers to chemotherapy

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Oligonucleotide analogue interference with the HIV-1 Tat protein-TAR RNA interaction

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Locked nucleic acids: a promising molecular family for gene-function analysis and antisense drug development

25 September 2017

1 reference

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Association of an RNA kissing complex analyzed using 2-aminopurine fluorescence

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Aptamers: selected oligonucleotides for therapy

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Synthetic oligonucleotides as RNA mimetics: 2'-modified Rnas and N3'-->P5' phosphoramidates

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Multiple biological roles associated with the repeat (R) region of the HIV-1 RNA genome

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Structural studies of LNA:RNA duplexes by NMR: conformations and implications for RNase H activity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Structure, recognition and discrimination in RNA aptamer complexes with cofactors, amino acids, drugs and aminoglycoside antibiotics

25 September 2017

1 reference

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A retroviral RNA kissing complex containing only two G⋅C base pairs

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

25 September 2017

1 reference

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Is a closing "GA pair" a rule for stable loop-loop RNA complexes?

25 September 2017

1 reference

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Effects of RNA secondary structure on cellular antisense activity

25 September 2017

1 reference

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In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA.

25 September 2017

1 reference

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Secondary structure determination of the conserved 98-base sequence at the 3' terminus of hepatitis C virus genome RNA

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Internal initiation of translation of hepatitis C virus RNA: the ribosome entry site is at the authentic initiation codon

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

A loop-loop "kissing" complex is the essential part of the dimer linkage of genomic HIV-1 RNA

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

Inhibition of HIV tat-TAR interactions by an antisense oligo-2'-O-methylribonucleoside methylphosphonate

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434442

The conformations of locked nucleic acids (LNA)

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15181175

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

2'-O-methyl-RNA hairpins generate loop-loop complexes and selectively inhibit HIV-1 Tat-mediated transcription

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15181175

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKH636

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15181175%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15181175%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

15181175

1 reference