Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways (Q41146978)

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scientific article published on 26 March 2015

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English	Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways	scientific article published on 26 March 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

27 September 2017

Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

author name string

Shweta Shrivastava

1

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Europe PubMed Central

PubMed publication ID

27 September 2017

Manish Kumar Jeengar

2

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

V Sudhakar Reddy

3

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

G Bhanuprakash Reddy

4

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Europe PubMed Central

PubMed publication ID

27 September 2017

V G M Naidu

5

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Europe PubMed Central

PubMed publication ID

27 September 2017

language of work or name

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publication date

26 March 2015

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Europe PubMed Central

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27 September 2017

Experimental and Molecular Pathology

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27 September 2017

98

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Europe PubMed Central

PubMed publication ID

27 September 2017

3

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Europe PubMed Central

PubMed publication ID

27 September 2017

313-327

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Europe PubMed Central

PubMed publication ID

27 September 2017

Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-κB signalling and G0/G1 cell cycle arrest: a bioassay-guided approach.

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Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer

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Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB

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Tissue sulfhydryl groups

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Mitochondria as the target of the pro-apoptotic protein Bax.

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Triple-Negative Breast Cancer

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Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol

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1 reference

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Identifiers

10.1016/J.YEXMP.2015.03.031

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

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