Modeling backbone flexibility to achieve sequence diversity: the design of novel alpha-helical ligands for Bcl-xL. (Q41365386)

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1 January 2020

title

Modeling backbone flexibility to achieve sequence diversity: the design of novel alpha-helical ligands for Bcl-xL (English)

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2

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Amy Keating

series ordinal

3

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author name string

Xiaoran Fu

series ordinal

1

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language of work or name

English

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publication date

5 May 2007

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Journal of Molecular Biology

1 January 2020

published in

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volume

371

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issue

4

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1 January 2020

page(s)

1099-1117

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The dead-end elimination theorem and its use in protein side-chain positioning

1 January 2020

cites work

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Structural insights into the degradation of Mcl-1 induced by BH3 domains

1 October 2017

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Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein

1 October 2017

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Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

1 October 2017

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

1 October 2017

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Computer-based design of novel protein structures

1 October 2017

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Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles

1 October 2017

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 October 2017

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Usefulness and limitations of normal mode analysis in modeling dynamics of biomolecular complexes

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 October 2017

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Paralog-selective ligands for bcl-2 proteins

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 October 2017

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Recapitulation of protein family divergence using flexible backbone protein design

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Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

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An analysis of core deformations in protein superfamilies

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Flexibility of beta-sheets: principal component analysis of database protein structures

1 October 2017

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The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

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Computational design of receptor and sensor proteins with novel functions

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1 October 2017

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The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

1 October 2017

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Thoroughly sampling sequence space: large-scale protein design of structural ensembles

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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Development of a high-throughput fluorescence polarization assay for Bcl-x(L)

1 October 2017

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DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis

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Enzyme-like proteins by computational design

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Design and Evolution of a Miniature Bcl-2 Binding Protein We thank the HHMI Biopolymer/Keck Foundation Biotechnology Resource Laboratory (Yale University School of Medicine, New Haven, CT) for oligonucleotide and peptide synthesis and amino acid ana

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Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

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Statistical theory for protein combinatorial libraries. Packing interactions, backbone flexibility, and the sequence variability of a main-chain structure.

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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

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19 August 2018

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19 August 2018

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2 December 2018

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Flexibility of alpha-helices: results of a statistical analysis of database protein structures

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Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition

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