Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes. (Q41478915)

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14 February 2020

title

Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes (English)

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14 February 2020

9

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author name string

Linyuan Wang

1

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14 February 2020

Yunfeng Liu

2

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14 February 2020

Shun Yan Lu

3

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14 February 2020

Kinh-Tung T Nguyen

4

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14 February 2020

Stephanie A Schroer

5

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14 February 2020

Akira Suzuki

6

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14 February 2020

Tak W Mak

7

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Herbert Gaisano

8

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language of work or name

English

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publication date

17 September 2010

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14 February 2020

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14 February 2020

volume

59

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issue

12

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page(s)

3117-3126

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

14 February 2020

copyright license

start time

28 August 2021

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Role of tumor suppressor PTEN in tumor necrosis factor alpha-induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells

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Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo

11 June 2018

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Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes

11 June 2018

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Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue

11 June 2018

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Muscle-specific Pten deletion protects against insulin resistance and diabetes

11 June 2018

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Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

11 June 2018

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Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose

11 June 2018

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Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

11 June 2018

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

11 June 2018

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Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

11 June 2018

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Insulin signalling and the regulation of glucose and lipid metabolism

11 June 2018

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Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

11 June 2018

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Beta cell failure: causes and consequences

11 June 2018

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beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms.

11 June 2018

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Regulation of gene expression by glucose in pancreatic beta -cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3'-kinase.

11 June 2018

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The importance of the beta-cell in the pathogenesis of type 2 diabetes mellitus

11 June 2018

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

11 June 2018

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

11 June 2018

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The relationship of diabetes, loss of glucose-induced insulin secretion, and GLUT2.

11 June 2018

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Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance.

11 June 2018

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Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes

11 June 2018

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PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells.

11 June 2018

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PTEN expression contributes to the regulation of muscle protein degradation in diabetes.

19 August 2018

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Type 2 diabetes-a matter of beta-cell life and death?

19 August 2018

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Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

19 August 2018

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Increase of PTEN gene expression in insulin resistance

19 August 2018

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Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes

19 August 2018

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Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

19 August 2018

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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

19 August 2018

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beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass

19 August 2018

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Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

19 August 2018

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

19 August 2018

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Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production

19 August 2018

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12 December 2020

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes

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12 December 2020

Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models

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12 December 2020

Partial deletion of Pten in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone

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12 December 2020

Identifiers

DOI

10.2337/DB09-1805

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20852026%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

0 references

1 reference

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14 February 2020

PubMed publication ID

20852026

1 reference