Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate. (Q41487882)

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scientific article published on July 2006

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English	Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.	scientific article published on July 2006

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scholarly article

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30 August 2019

Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate (English)

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30 August 2019

farnesyl pyrophosphate synthase

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farnesyl pyrophosphate synthase

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Leishmania major

object named as

Leishmania major

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Antonio M Estévez

3

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Luis Miguel Ruiz-Pérez

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Dolores Gonzalez-Pacanowska

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author name string

Aurora Ortiz-Gómez

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Carmen Jiménez

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Juana Carrero-Lérida

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1 July 2006

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Eukaryotic Cell

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1057-1064

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30 August 2019

Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.

1 reference

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Leishmaniasis: current situation and new perspectives

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Mevalonate kinase is a cytosolic enzyme in humans

1 reference

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Phosphomevalonate kinase is a cytosolic protein in humans

1 reference

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Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae

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In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

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Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

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The biosynthetic incorporation of the intact leucine skeleton into sterol by the trypanosomatid Leishmania mexicana.

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Structures of type 2 peroxisomal targeting signals in two trypanosomatid aldolases

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Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

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Molecular analysis of prenyl chain elongating enzymes

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Developments in the therapeutic applications of bisphosphonates

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Localization of farnesyl diphosphate synthase in chloroplasts

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The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth

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11 June 2018

Overview of bisphosphonates

1 reference

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11 June 2018

Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.

1 reference

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11 June 2018

Compartmentalization of cholesterol biosynthesis. Conversion of mevalonate to farnesyl diphosphate occurs in the peroxisomes

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11 June 2018

Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution

1 reference

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Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genes

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Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase

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Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design

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Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase.

1 reference

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3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

1 reference

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Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes. AA-CoA thiolase, hmg-coa synthase, MPPD, and FPP synthase

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold Dictyostelium discoideum

1 reference

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based on heuristic

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Calcium-sequestering organelles of Dictyostelium discoideum: changes in element content during early development as measured by electron probe X-ray microanalysis

1 reference

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1 reference

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inferred from PubMed ID database lookup

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/EC.00034-06

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Europe PubMed Central

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30 August 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16835450%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16835450%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

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