Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis. (Q41584686)

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scientific article published on 5 April 2016

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English	Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.	scientific article published on 5 April 2016

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31 March 2020

Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis (English)

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31 March 2020

polycystic kidney disease

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Hervé Husson

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31 March 2020

Sarah Moreno

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31 March 2020

Laurie A Smith

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31 March 2020

Mandy M Smith

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31 March 2020

Ryan J Russo

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Rose Pitstick

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31 March 2020

Steven R Ledbetter

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31 March 2020

Nikolay O Bukanov

9

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31 March 2020

Monica Lane

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31 March 2020

Kate Zhang

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31 March 2020

Katy Billot

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31 March 2020

George Carlson

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31 March 2020

Jagesh Shah

14

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31 March 2020

David R Beier

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31 March 2020

Oxana Ibraghimov-Beskrovnaya

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31 March 2020

publication date

5 April 2016

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31 March 2020

Human Molecular Genetics

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31 March 2020

25

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31 March 2020

11

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31 March 2020

2245-2255

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31 March 2020

Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Loss of the ciliary kinase Nek8 causes left-right asymmetry defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Modeling human disease in humans: the ciliopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Why kidneys fail in autosomal dominant polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Cyclin-dependent kinases in brain development and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Polycystic kidney disease: pathogenesis and potential therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Mechanisms of nephronophthisis and related ciliopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Diagnosis of autosomal-dominant polycystic kidney disease: an integrated approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Imaging intraflagellar transport in mammalian primary cilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Primary cilia and the cell cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Cdk5, the multifunctional surveyor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

A case for water in the treatment of polycystic kidney disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

TGF-beta mediated epithelial-mesenchymal transition in autosomal dominant polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Ciliary dysfunction in developmental abnormalities and diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Nek8 regulates the expression and localization of polycystin-1 and polycystin-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

The Ciliopathies: An Emerging Class of Human Genetic Disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Roscovitine targets, protein kinases and pyridoxal kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

CRMP-2 binds to tubulin heterodimers to promote microtubule assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

6 June 2018

Cdk5 in the centriolar appendages mediates cenexin1 localization and primary cilia formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

19 August 2018

Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.

1 reference

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19 August 2018

Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease.

1 reference

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19 August 2018

Limitation of podocyte proliferation improves renal function in experimental crescentic glomerulonephritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

19 August 2018

Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

19 August 2018

Reversal of collapsing glomerulopathy in mice with the cyclin-dependent kinase inhibitor CYC202.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

19 August 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

19 August 2018

A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

19 August 2018

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1 reference

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19 August 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5081056

19 August 2018

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1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW093

21 January 2018

Nephronophthisis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27053712

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tolvaptan in autosomal dominant polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27053712

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epithelial-to-mesenchymal transition in cyst lining epithelial cells in an orthologous PCK rat model of autosomal-recessive polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27053712

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/27053712

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneys

1 reference

https://pubmed.ncbi.nlm.nih.gov/27053712

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/HMG/DDW093

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Europe PubMed Central

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31 March 2020

PMC publication ID

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31 March 2020

PubMed publication ID

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Europe PubMed Central

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31 March 2020

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