The mechanism of action of methotrexate (Q41635846)

5 October 2017

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title

The mechanism of action of methotrexate (English)

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5 October 2017

Cronstein BN

1

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5 October 2017

1 November 1997

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Rheumatic Diseases Clinics of North America

5 October 2017

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5 October 2017

23

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5 October 2017

4

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5 October 2017

739-755

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Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid arthritis. Evidence for differential influences of therapy and clinical status on IgM and IgA rheumatoid factor expression

5 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Weekly pulse methotrexate in rheumatoid arthritis. Clinical and immunologic effects in a randomized, double-blind study.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Alteration of purine metabolism by AICA-riboside in human B lymphoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Aminophylline for methotrexate-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Alteration of interleukin-1 production and the acute phase response following medication of adjuvant arthritic rats with cyclosporin-A or methotrexate

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

3-deaza-adenosine inhibition of stimulus-response coupling in human polymorphonuclear leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Increased polyamines may downregulate interleukin 2 production in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Regulation of IL-2 production by mononuclear cells from rheumatoid arthritis synovial fluids

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Abnormalities in S-adenosylhomocysteine hydrolysis, ATP catabolism, and lymphoid differentiation in adenosine deaminase deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Inhibition of neutrophil adherence to endothelial cells by 3-deazaadenosine

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Role of S-adenosylhomocysteine in adenosine-mediated toxicity in cultured mouse T lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Fish-oil fatty acid supplementation in active rheumatoid arthritis. A double-blinded, controlled, crossover study

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Long-term prospective study of the use of methotrexate in the treatment of rheumatoid arthritis. Update after a mean of 90 months

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Imidazo[4,5-c]pyridines (3-deazapurines) and their nucleosides as immunosuppressive and antiinflammatory agents

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Adenosine A2 receptor-induced inhibition of leukotriene B4 synthesis in whole blood ex vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Circulating interleukin 10 and interleukin-6 serum levels in rheumatoid arthritis patients treated with methotrexate or gold salts: preliminary report

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

The action of the adenosylhomocysteine hydrolase inhibitor, 3-deazaadenosine, on phagocytic function of mouse macrophages and human monocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

The effects of (R)-N-(1-methyl-2-phenylethyl) adenosine (L-PIA), a standard A1-selective adenosine agonist on rat acute models of inflammation and neutrophil function

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Aminoimidazolecarboxamide excretion in vitamin-B12 and folic-acid deficiencies

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Abnormal adenosine-induced immunosuppression and cAMP metabolism in T lymphocytes of patients with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

The in vitro effects of methotrexate on peripheral blood mononuclear cells. Modulation by methyl donors and spermidine

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

In vitro effects of methotrexate on peripheral blood monocytes: modulation by folinic acid and S-adenosylmethionine

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Adenosine receptor subtypes: characterization and therapeutic regulation

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

IgM-rheumatoid factor and responses to second-line drugs in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Characterization of the human T lymphocyte adenosine receptor: comparison of normal and systemic lupus erythematosus cells

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

The effects of methotrexate on the production and activity of interleukin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Rescue of interleukin-1 activity by leucovorin following inhibition by methotrexate in a murine in vitro system

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Interleukin-8 in inflammatory rheumatic diseases: synovial fluid levels, relation to rheumatoid factors, production by mononuclear cells, and effects of gold sodium thiomalate and methotrexate

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Elevated levels of TNF in the joints of adjuvant arthritic rats

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Role of transmethylation reactions in cellular motility and phagocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Acute and chronic suppression of leukotriene B4 synthesis EX vivo in neutrophils from patients with rheumatoid arthritis beginning treatment with methotrexate

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

3-Deazaadenosine-induced disorganization of macrophage microfilaments

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

A randomized, double-blind, placebo-controlled study of CD4 monoclonal antibody therapy in early rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Cell-type specific response of peripheral blood lymphocytes to methotrexate in the treatment of rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Serum levels of interleukin-6 and tumour-necrosis-factor-alpha are not correlated to disease activity in patients with rheumatoid arthritis after treatment with low-dose methotrexate

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Efficacy of low-dose methotrexate in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Elevated mean corpuscular volume as a predictor of hematologic toxicity due to methotrexate therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Long-term prospective trial of low-dose methotrexate in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Prostaglandin and tumor necrosis factor secretion by peritoneal macrophages isolated from normal and arthritic rats treated with liposomal methotrexate

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

The effect of liposomally conjugated methotrexate upon mediator release from human peripheral blood monocytes

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https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Effect of three lipophilic methotrexate derivatives upon mediator release by lipopolysaccharide-stimulated rat peritoneal macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Effect of liposomally encapsulated MTX-DMPE conjugates upon TNF alpha and PGE2 release by lipopolysaccharide stimulated rat peritoneal macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

Inhibition of lymphocyte-mediated cytolysis by 3-deazaadenosine: Evidence for a methylation reaction essential to cytolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0889-857X%2805%2970358-6

7 January 2021

10.1016/S0889-857X(05)70358-6

Identifiers

DOI

1 reference

5 October 2017

1 reference

PubMed ID

9361153