Alzheimer's disease: a re-examination of the amyloid hypothesis (Q41701342)

7 October 2017

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title

Alzheimer's disease: a re-examination of the amyloid hypothesis (English)

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7 October 2017

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Neve RL

1

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7 October 2017

Robakis NK

series ordinal

2

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7 October 2017

publication date

1 January 1998

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7 October 2017

published in

Trends in Neurosciences

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7 October 2017

volume

21

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7 October 2017

issue

1

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7 October 2017

page(s)

15-19

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The Alzheimer family of diseases: many etiologies, one pathogenesis?

7 October 2017

cites work

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7 January 2021

Amyloid beta-protein and the genetics of Alzheimer's disease

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7 January 2021

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

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7 January 2021

Evidence that A beta 42 is the real culprit in Alzheimer's disease.

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7 January 2021

Involvement of amyloid as a central step in the development of Alzheimer's disease

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7 January 2021

Amyloid beta protein enhances the survival of hippocampal neurons in vitro

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7 January 2021

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

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7 January 2021

Neurotoxicity of A beta amyloid protein in vitro is not altered by calcium channel blockade

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7 January 2021

Soluble beta-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels

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7 January 2021

Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease

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7 January 2021

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum

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7 January 2021

beta-Amyloid polypeptide increases calcium-uptake in PC12 cells: a possible mechanism for its cellular toxicity in Alzheimer's disease.

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7 January 2021

Hydrogen peroxide mediates amyloid beta protein toxicity

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7 January 2021

Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation

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7 January 2021

Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide.

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7 January 2021

Inhibitors of free radical formation fail to attenuate direct beta-amyloid25-35 peptide-mediated neurotoxicity in rat hippocampal cultures.

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7 January 2021

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

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7 January 2021

Surface Phosphorylation by Ecto‐Protein Kinase C in Brain Neurons: A Target for Alzheimer's β‐Amyloid Peptides

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7 January 2021

Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro

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7 January 2021

Increased production of matrix metalloproteinases in enriched astrocyte and mixed hippocampal cultures treated with beta-amyloid peptides.

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7 January 2021

Neurocytopathic effects of beta-amyloid-stimulated monocytes: a potential mechanism for central nervous system damage in Alzheimer disease

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7 January 2021

beta-Amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarized hippocampal slices.

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7 January 2021

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7 January 2021

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

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7 January 2021

Amyloid beta peptide induces necrosis rather than apoptosis.

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7 January 2021

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

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7 January 2021

Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

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https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.

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7 January 2021

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7 January 2021

Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro

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7 January 2021

Neurite outgrowth on postmortem human brain cryostat sections: studies of non-Alzheimer's and Alzheimer's tissue.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

An analysis of the effects of Alzheimer's plaques on living neurons.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Deposits of A beta fibrils are not toxic to cortical and hippocampal neurons in vitro

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7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Lack of long-term effects after beta-amyloid protein injections in rat brain

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7 January 2021

In vivo effects of beta-amyloid implants in rodents: lack of potentiation of damage associated with transient global forebrain ischemia

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7 January 2021

Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs.

1 reference

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7 January 2021

Age-dependent spatial memory deficits in transgenic mice expressing the human mid-sized neurofilament gene: I.

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7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease.

1 reference

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7 January 2021

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

1 reference

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7 January 2021

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

1 reference

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7 January 2021

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

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7 January 2021

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Regional Distribution of Neurofibrillary Tangles and Senile Plaques in the Cerebral Cortex of Elderly Patients: A Quantitative Evaluation of a One-Year Autopsy Population from a Geriatric Hospital

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Deposition of ?/A4 protein along neuronal plasma membranes in diffuse senile plaques

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Aggregation of beta-amyloid peptide is promoted by membrane phospholipid metabolites elevated in Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

1 reference

7 January 2021

The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Apolipoprotein E, memory and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Alzheimer's disease: clinical implications of the apolipoprotein E genotype

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: the role of the complement system

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Radical AGEing in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

NMDA and AMPA receptors in transgenic mice expressing human beta-amyloid protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

Mechanism of Alzheimer neurofibrillary degeneration and the formation of tangles.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2897%2901168-5

7 January 2021

10.1016/S0166-2236(97)01168-5

Identifiers

DOI

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7 October 2017

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