Apoptosis by p53: mechanisms, regulation, and clinical implications (Q41737530)

8 October 2017

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title

Apoptosis by p53: mechanisms, regulation, and clinical implications (English)

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8 October 2017

Sionov RV

1

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PubMed ID

9540161

8 October 2017

Haupt Y

series ordinal

2

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8 October 2017

1 January 1998

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Seminars in Immunopathology

8 October 2017

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8 October 2017

19

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8 October 2017

3

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8 October 2017

345-362

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https://scigraph.springernature.com/pub.10.1007/bf00787230

8 October 2017

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cites work

Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF00787230

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

21 January 2018

1 reference

12 December 2020

New insights into p53 function from structural studies

1 reference

12 December 2020

Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion.

1 reference

12 December 2020

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

1 reference

12 December 2020

Biological and clinical importance of the p53 tumor suppressor gene.

1 reference

12 December 2020

Cell type-specific inhibition of p53-mediated apoptosis by mdm2.

1 reference

12 December 2020

The cellular effects of E2F overexpression

1 reference

12 December 2020

Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA to human cervical cancer cells

1 reference

12 December 2020

p53, the cellular gatekeeper for growth and division

1 reference

12 December 2020

Neoangiogenesis and p53 protein in lung cancer: their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression

1 reference

12 December 2020

Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes.

1 reference

12 December 2020

Interaction between ATM protein and c-Abl in response to DNA damage

1 reference

12 December 2020

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

1 reference

12 December 2020

Essential role for p53-mediated transcription in E1A-induced apoptosis

1 reference

12 December 2020

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

1 reference

12 December 2020

Life, death, and the pursuit of apoptosis.

1 reference

12 December 2020

p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells

1 reference

12 December 2020

Transferrin-liposome-mediated p53 sensitization of squamous cell carcinoma of the head and neck to radiation in vitro

1 reference

12 December 2020

Wilms' tumor 1-KTS isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor.

1 reference

12 December 2020

Antisense technology and prospects for therapy of viral infections and cancer

1 reference

12 December 2020

A novel p53 germline alteration identified in a late onset breast cancer kindred

1 reference

12 December 2020

Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53.

1 reference

12 December 2020

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1 reference

12 December 2020

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1 reference

12 December 2020

The growth-inhibitory function of p53 is separable from transactivation, apoptosis and suppression of transformation by E1a and Ras

1 reference

12 December 2020

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

1 reference

12 December 2020

p53 in growth control and neoplasia

1 reference

12 December 2020

The humoral response to the tumor-suppressor gene-product p53 in human cancer: implications for diagnosis and therapy

1 reference

12 December 2020

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

12 December 2020

Expression of p53, glutathione S-transferase-pi, and Bcl-2 proteins and benefit from adjuvant radiotherapy in breast cancer

1 reference

12 December 2020

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

12 December 2020

MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis

1 reference

12 December 2020

p53--integrating the complexity

1 reference

12 December 2020

Two functional assays employed to detect an unusual mutation in the oligomerisation domain of p53 in a Li-Fraumeni like family

1 reference

12 December 2020

p53 and ATM: cell cycle, cell death, and cancer.

1 reference

12 December 2020

p53 as a target for anti-cancer immunotherapy

1 reference

12 December 2020

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis

1 reference

12 December 2020

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1 reference

12 December 2020

A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

1 reference

12 December 2020

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

1 reference

12 December 2020

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis

1 reference

12 December 2020

Nuclear accumulation of mutant p53 protein: a possible predictor of failure of intravesical therapy in bladder cancer

1 reference

12 December 2020

Gene delivery into malignant cells in vivo by a conjugated adenovirus/DNA complex.

1 reference

12 December 2020

Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer

1 reference

12 December 2020

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

1 reference

12 December 2020

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

12 December 2020

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

12 December 2020

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

1 reference

12 December 2020

The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype

1 reference

12 December 2020

Tumor suppressors: a developing role for p53?

1 reference

12 December 2020

Clinical implications of the p53 gene

1 reference

12 December 2020

T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.

1 reference

12 December 2020

The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.

1 reference

12 December 2020

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

1 reference

12 December 2020

Identification of novel mdm2 binding peptides by phage display.

1 reference

12 December 2020

Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression

1 reference

12 December 2020

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

12 December 2020

Gene therapy for cancer: what have we done and where are we going?

1 reference

12 December 2020

Role of p53 in drug resistance in ovarian cancer

1 reference

12 December 2020

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

12 December 2020

p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge.

1 reference

12 December 2020

p53-mediated apoptosis in HeLa cells can be overcome by excess pRB

1 reference

12 December 2020

p53; from inductive signal to cellular effect

1 reference

12 December 2020

The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

1 reference

12 December 2020

Regulation of apoptosis by viral gene products

1 reference

12 December 2020

Therapeutic targeting of the p53 tumor suppressor gene

1 reference

12 December 2020

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

1 reference

12 December 2020

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1 reference

12 December 2020

Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines

1 reference

12 December 2020

Recruitment of p300/CBP in p53-dependent signal pathways

1 reference

12 December 2020

p53 in signaling checkpoint arrest or apoptosis

1 reference

12 December 2020

Identification of a p53-dependent negative response element in the bcl-2 gene

1 reference

12 December 2020

p53-mediated apoptosis: mechanisms and regulation

1 reference

12 December 2020

The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M

1 reference

12 December 2020

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1 reference

12 December 2020

Immunohistochemical detection of bcl-2 and p53 proteins and apoptosis in soft tissue sarcoma: their correlations with prognosis

1 reference

12 December 2020

Failure to dephosphorylate retinoblastoma protein in drug-resistant cells

1 reference

12 December 2020

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas

1 reference

12 December 2020

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

1 reference

12 December 2020

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

1 reference

12 December 2020

p53: puzzle and paradigm

1 reference

12 December 2020

Role for c-Abl tyrosine kinase in growth arrest response to DNA damage.

1 reference

12 December 2020

Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies

1 reference

12 December 2020

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products

1 reference

12 December 2020

Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest.

1 reference

12 December 2020

DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies

1 reference

12 December 2020

Wild-type p53 negatively regulates the expression of a microtubule-associated protein

1 reference

12 December 2020

P53 gene alterations in human tumors: perspectives for cancer control.

1 reference

12 December 2020

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells

1 reference

12 December 2020

The mdm-2 gene is induced in response to UV light in a p53-dependent manner

1 reference

12 December 2020

Small peptides activate the latent sequence-specific DNA binding function of p53.

1 reference

12 December 2020

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1 reference

12 December 2020

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1 reference

12 December 2020

Complex formation between the lymphotropic papovavirus large tumor antigen and the tumor suppressor protein p53.

1 reference

12 December 2020

Gas1-induced growth suppression requires a transactivation-independent p53 function

1 reference

12 December 2020

Mdm2 promotes the rapid degradation of p53

1 reference

12 December 2020

Viruses and apoptosis

1 reference

12 December 2020

1 reference

12 December 2020

A simple p53 functional assay for screening cell lines, blood, and tumors

1 reference

12 December 2020

How phosphorylation regulates the activity of p53.

1 reference

12 December 2020

The role of p53 as a transcription factor in the induction of apoptosis

1 reference

12 December 2020

A p53-dependent mouse spindle checkpoint

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00787230

1 reference

8 October 2017

1 reference

PubMed ID

9540161