Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration (Q41821246)

12 October 2017

Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration (English)

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12 October 2017

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Maulik Patel

1

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12 October 2017

Takeharu Kawano

2

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12 October 2017

Nobuchika Suzuki

3

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12 October 2017

Takao Hamakubo

4

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12 October 2017

Andrei V Karginov

5

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12 October 2017

Tohru Kozasa

6

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12 October 2017

23 June 2014

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12 October 2017

Molecular Pharmacology

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12 October 2017

86

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12 October 2017

3

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12 October 2017

252-262

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describes a project that uses

12 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4576495/fullTextXML

inferred from PubMed Central ID database lookup

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6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

6 June 2018

1 reference

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Characterization of gastrin-releasing peptide and its receptor aberrantly expressed by human colon cancer cell lines

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells

6 June 2018

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Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2

6 June 2018

1 reference

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Galpha(13) stimulates Rho-dependent activation of the cyclooxygenase-2 promoter

6 June 2018

1 reference

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Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

Constitutive activation of the gastrin-releasing peptide receptor expressed by the nonmalignant human colon epithelial cell line NCM460.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

6 June 2018

1 reference

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Altered eicosanoid levels in human colon cancer

6 June 2018

1 reference

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Purification and characterization of the alpha subunit of G13.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

Inhibition of growth of HT-29 human colon cancer xenografts in nude mice by treatment with bombesin/gastrin releasing peptide antagonist (RC-3095)

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

Rho GTPases are over-expressed in human tumors.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576495

RGS3 is a GTPase-activating protein for g(ialpha) and g(qalpha) and a potent inhibitor of signaling by GTPase-deficient forms of g(qalpha) and g(11alpha)

18 August 2018

1 reference

12 December 2020

Determination of GTP loading on Rho

1 reference

12 December 2020

Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells

1 reference

12 December 2020

Aberrant expression of gastrin-releasing peptide and its receptor by well-differentiated colon cancers in humans

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12 December 2020

Transient upregulation of GRP and its receptor critically regulate colon cancer cell motility during remodeling

1 reference

12 December 2020

Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells

1 reference

12 December 2020

Identifiers

DOI

10.1124/MOL.114.093914

1 reference

12 October 2017

1 reference

12 October 2017

PubMed publication ID

24958816

1 reference