Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells (Q41871104)

13 October 2017

Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells (English)

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13 October 2017

1

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13 October 2017

Luigi Puglielli

2

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13 October 2017

Blake C Ellis

series ordinal

3

1 reference

13 October 2017

Laura A MacKenzie Ingano

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4

1 reference

13 October 2017

Dora M Kovacs

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5

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13 October 2017

10 July 2008

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Journal of Molecular Neuroscience

13 October 2017

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13 October 2017

37

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13 October 2017

1

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13 October 2017

6-15

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https://scigraph.springernature.com/pub.10.1007/s12031-008-9088-0

13 October 2017

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Knockdown of ACAT-1 reduces amyloidogenic processing of APP

5 June 2018

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5 June 2018

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Neuronal membrane cholesterol loss enhances amyloid peptide generation

5 June 2018

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

5 June 2018

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Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease

5 June 2018

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Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

5 June 2018

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Alzheimer's disease: the cholesterol connection

5 June 2018

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

5 June 2018

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

5 June 2018

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A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

5 June 2018

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Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

5 June 2018

1 reference

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7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome

5 June 2018

1 reference

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Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

5 June 2018

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Statins and the risk of dementia

5 June 2018

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Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

5 June 2018

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Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

5 June 2018

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Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site

5 June 2018

1 reference

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Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles

5 June 2018

1 reference

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The role of cholesterol in the biosynthesis of beta-amyloid

5 June 2018

1 reference

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

5 June 2018

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

5 June 2018

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Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

5 June 2018

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Cholesterol modification of hedgehog signaling proteins in animal development

5 June 2018

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

5 June 2018

1 reference

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

5 June 2018

1 reference

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VIP21/caveolin is a cholesterol-binding protein

5 June 2018

1 reference

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

5 June 2018

1 reference

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The use of measured genotype information in the analysis of quantitative phenotypes in man. II. The role of the apolipoprotein E polymorphism in determining levels, variability, and covariability of cholesterol, betalipoprotein, and triglycerides in

5 June 2018

1 reference

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Isolation and characterization of Chinese hamster ovary cell mutants deficient in acyl-coenzyme A:cholesterol acyltransferase activity.

5 June 2018

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Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

5 June 2018

1 reference

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

5 June 2018

1 reference

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Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.

5 June 2018

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The Alzheimer amyloid precursor is associated with the detergent- insoluble cytoskeleton

5 June 2018

1 reference

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HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.

5 June 2018

1 reference

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Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

18 August 2018

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The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721794

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721794

Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721794

Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721794

Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721794

A detergent-insoluble membrane compartment contains A beta in vivo

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721794

Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18618086

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18618086

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Alzheimer's amyloid beta interaction with normal human plasma high density lipoprotein: association with apolipoprotein and lipids

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18618086

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S12031-008-9088-0

1 reference

Dimensions Publication ID

13 October 2017

0 references

1 reference

13 October 2017

PubMed publication ID

18618086

1 reference