Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin (Q46755710)

24 December 2017

title

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin (English)

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24 December 2017

author

Tobias Hartmann

11

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Marco Duering

6

object named as

Marco Duering

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8

Bart De Strooper

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Marcus O W Grimm

1

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Heike S Grimm

2

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Andreas J Pätzold

3

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Eva G Zinser

4

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Riikka Halonen

5

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Jakob A Tschäpe

7

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Ulrike Müller

9

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Jie Shen

10

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publication date

1 November 2005

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24 December 2017

published in

Nature Cell Biology

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volume

7

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issue

11

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page(s)

1118-1123

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https://scigraph.springernature.com/pub.10.1038/ncb1313

exact match

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cites work

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

7 January 2021

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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7 January 2021

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

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7 January 2021

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

1 reference

7 January 2021

Alzheimer's disease: the cholesterol connection

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7 January 2021

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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7 January 2021

Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

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7 January 2021

Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells

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7 January 2021

Modulation of amyloid precursor protein cleavage by cellular sphingolipids

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7 January 2021

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

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7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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7 January 2021

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

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7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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7 January 2021

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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7 January 2021

Neuronal membrane cholesterol loss enhances amyloid peptide generation

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7 January 2021

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

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7 January 2021

The levels of cerebrospinal fluid Abeta40 and Abeta42(43) are regulated age-dependently.

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7 January 2021

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

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7 January 2021

Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

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7 January 2021

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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7 January 2021

Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results.

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7 January 2021

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

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7 January 2021

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

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7 January 2021

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

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7 January 2021

Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

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7 January 2021

Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease

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7 January 2021

Oxidative stress induced by beta-amyloid peptide(1-42) is involved in the altered composition of cellular membrane lipids and the decreased expression of nicotinic receptors in human SH-SY5Y neuroblastoma cells

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7 January 2021

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

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7 January 2021

Identification of a family of animal sphingomyelin synthases

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7 January 2021

Identifiers

DOI

10.1038/NCB1313

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24 December 2017

release_o7xb5p5p7ngtjdhk54iz2d3num

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/o7xb5p5p7ngtjdhk54iz2d3num

24 November 2022

mapped directly with Wikidata item

PubMed ID

16227967

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24 December 2017