Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer (Q41942526)

14 October 2017

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer (English)

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14 October 2017

3

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Loren D. Walensky

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object named as

Loren D Walensky

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14 October 2017

Woojin Kim

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14 October 2017

Gregory H Bird

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14 October 2017

Tobias Neff

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14 October 2017

Guoji Guo

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14 October 2017

Marc A Kerenyi

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14 October 2017

Stuart H Orkin

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14 October 2017

25 August 2013

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14 October 2017

Nature Chemical Biology

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14 October 2017

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14 October 2017

10

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14 October 2017

643-650

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https://scigraph.springernature.com/pub.10.1038/nchembio.1331

14 October 2017

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cites work

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

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EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent

5 June 2018

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

5 June 2018

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

5 June 2018

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Cancer genetics and epigenetics: two sides of the same coin?

5 June 2018

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The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

5 June 2018

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Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM

5 June 2018

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Polycomb repressive complex 2 is required for MLL-AF9 leukemia

5 June 2018

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Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

5 June 2018

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EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR

5 June 2018

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CCAAT/enhancer binding protein alpha (C/EBP(alpha))-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation.

5 June 2018

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Context-specific regulation of NF-κB target gene expression by EZH2 in breast cancers.

5 June 2018

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EZH2 depletion blocks the proliferation of colon cancer cells

5 June 2018

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EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

5 June 2018

1 reference

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Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

5 June 2018

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Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

5 June 2018

1 reference

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The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

5 June 2018

1 reference

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Chromatin remodelling during development

5 June 2018

1 reference

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

5 June 2018

1 reference

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Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells

5 June 2018

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Direct inhibition of the NOTCH transcription factor complex

5 June 2018

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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

5 June 2018

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Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

5 June 2018

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EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

5 June 2018

1 reference

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Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis

5 June 2018

1 reference

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Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer

5 June 2018

1 reference

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Structural basis of EZH2 recognition by EED

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Expression of the polycomb group protein EZH2 and its relation to outcome in patients with urothelial carcinoma of the bladder

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

5 June 2018

1 reference

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

A stapled BID BH3 helix directly binds and activates BAX

5 June 2018

1 reference

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Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

5 June 2018

1 reference

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

5 June 2018

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Cell-penetrating peptides: tools for intracellular delivery of therapeutics.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Identification of human brain tumour initiating cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Mi-2/NuRD: multiple complexes for many purposes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

The polycomb group protein EZH2 is involved in progression of prostate cancer

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Hematopoietic progenitor/stem cells immortalized by Lhx2 generate functional hematopoietic cells in vivo

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Biological effects of inhibitors of S-adenosylhomocysteine hydrolase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778130

High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1331

CD133-positive hematopoietic stem cell "stemness" genes contain many genes mutated or abnormally expressed in leukemia

21 January 2018

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12 December 2020

Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells

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12 December 2020

Synergistic antileukemic action of a combination of inhibitors of DNA methylation and histone methylation

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12 December 2020

The distribution and turnover of labeled methyl groups in histone fractions of cultured mammalian cells

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1331

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14 October 2017

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14 October 2017

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