Substrate structure-activity relationships guide rational engineering of modular polyketide synthase ketoreductases (Q41968771)

14 October 2017

Substrate structure-activity relationships guide rational engineering of modular polyketide synthase ketoreductases (English)

1 reference

14 October 2017

1

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7 June 2020

author name string

Marjolein E Pasman

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26568113%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Adrian T Keatinge-Clay

series ordinal

3

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7 June 2020

language of work or name

English

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publication date

16 November 2015

1 reference

14 October 2017

Chemical Communications

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7 June 2020

volume

52

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issue

4

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7 June 2020

page(s)

792-795

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Structural and functional studies of atrans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction

7 June 2020

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Crystal structure of (R)-3-hydroxybutyryl-CoA dehydrogenase PhaB from Ralstonia eutropha

5 June 2018

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Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

5 June 2018

1 reference

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The structures of type I polyketide synthases

5 June 2018

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Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase

5 June 2018

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The biosynthetic logic of polyketide diversity

5 June 2018

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A tylosin ketoreductase reveals how chirality is determined in polyketides

5 June 2018

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Modern aldol methods for the total synthesis of polyketides

5 June 2018

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Ketoreduction in mycolactone biosynthesis: insight into substrate specificity and stereocontrol from studies of discrete ketoreductase domains in vitro

5 June 2018

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Substrate-dependent stereospecificity of Tyl-KR1: an isolated polyketide synthase ketoreductase domain from Streptomyces fradiae.

5 June 2018

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Preparative, in vitro biocatalysis of triketide lactone chiral building blocks.

18 August 2018

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Insights into the stereospecificity of ketoreduction in a modular polyketide synthase.

18 August 2018

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The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates.

18 August 2018

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High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase.

18 August 2018

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Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.

18 August 2018

1 reference

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The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.

18 August 2018

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Broad substrate specificity of ketoreductases derived from modular polyketide synthases.

18 August 2018

1 reference

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Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

18 August 2018

1 reference

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A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

18 August 2018

1 reference

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Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase

18 August 2018

1 reference

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Around and beyond Cram's Rule.

18 August 2018

1 reference

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18 August 2018

Asymmetric hydrogenation

1 reference

Crossref

https://api.crossref.org/works/10.1039%2FC5CC07315D

Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide Synthases

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26568113

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26568113

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Filling gaps in asymmetric hydrogenation methods for acyclic stereocontrol: application to chirons for polyketide-derived natural products

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26568113

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1039/C5CC07315D

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26568113%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26568113%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

26568113

1 reference